1610046-01-9

Basic information

• Product Name: C₁₉H₂₀O₂
• CAS NO: 1610046-01-9
• Molecular Weight: 280.367
• Mol File: 1610046-01-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₀O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₀O₂(1610046-01-9)
• EPA Substance Registry System: C₁₉H₂₀O₂(1610046-01-9)

Safety Data

• Hazardous Substances Data: 1610046-01-9(Hazardous Substances Data)

Upstream product

• 22543-74-4 4-tert-butylbenzhydrol 
• 100-59-4 phenylmagnesium chloride 
• 1450760-27-6 (E)-ethyl 3-(4-tert-butylphenyl)-3-phenylacrylate 
• 22679-54-5 4-tert-butylbenzophenone 
• 939-97-9 4-tert-Butylbenzaldehyde 

Downstream Products

• 1450760-15-2 (E)-3-(4-tert-butylphenyl)-N-[3-fluoro-4-(methylsulfonamido)benzyl]-3-phenylacrylamide 

Relevant articles and documents

Design, synthesis and biological evaluation of B-region modified diarylalkyl amide analogues as novel TRPV1 antagonists

Design, synthesis and biological evaluation of B-region, known to be a dipolar interacting pharmacophore, modified diarylalkyl amide analogues for novel TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) antagonists was described. A variety of moieties including guanidines, heterocyclic rings, cinnamides, and α-substituted acetamides were introduced at the B-region. TRPV1 antagonistic activities of these analogues were evaluated by 45Ca2+ uptake assay in rat DRG neuron. In particular, α,α-difluoroamide 53 exhibited 3-fold more potent TRPV1 antagonistic activity (IC50 = 0.058 μM) than the parent amide analogue 6.