Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1610605-76-9

Post Buying Request

1610605-76-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1610605-76-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1610605-76-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,0,6,0 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1610605-76:
(9*1)+(8*6)+(7*1)+(6*0)+(5*6)+(4*0)+(3*5)+(2*7)+(1*6)=129
129 % 10 = 9
So 1610605-76-9 is a valid CAS Registry Number.

1610605-76-9Relevant articles and documents

Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase

Chapron, Christopher,Glen, Rebecca,La Colla, Massimiliano,Mayes, Benjamin A.,McCarville, Joseph F.,Moore, Stephen,Moussa, Adel,Sarkar, Ruhul,Seifer, Maria,Serra, Ilaria,Stewart, Alistair

, p. 2699 - 2702 (2014)

The synthesis of 2′-O,4′-C-methylene-bridged bicyclic guanine ribonucleosides bearing 2′-C-methyl or 5′-C-methyl modifications is described. Key to the successful installation of the methyl functionality in both cases was the use of a one-pot oxidation-Grignard procedure to avoid formation of the respective unreactive hydrates prior to alkylation. The 2′-C-methyl- and 5′-C-methyl-modified bicyclic guanosines were evaluated, along with the known uracil-, cytosine-, adenine-, guanine-LNA and guanine-ENA nucleosides, as potential antiviral agents and found to be inactive in the hepatitis C virus (HCV) cell-based replicon assay. Examination of the corresponding nucleoside triphosphates, however, against the purified HCV NS5B polymerase indicated that LNA-G and 2′-C-methyl-LNA-G are potent inhibitors of both 1b wild type and S282T mutant enzymes in vitro. Activity was further demonstrated for the LNA-G-triphosphate against HCV NS5B polymerase genotypes 1a, 2a, 3a and 4a. A phosphorylation by-pass prodrug strategy may be required to promote anti-HCV activity in the replicon assay.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1610605-76-9