1610734-19-4

Basic information

• Product Name: N,N-diethyl-2-phenyl-2-(o-tolyl)acetamide
• Synonyms: N,N-diethyl-2-phenyl-2-(o-tolyl)acetamide
• CAS NO: 1610734-19-4
• Molecular Weight: 281.398
• Mol File: 1610734-19-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-2-phenyl-2-(o-tolyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-phenyl-2-(o-tolyl)acetamide(1610734-19-4)
• EPA Substance Registry System: N,N-diethyl-2-phenyl-2-(o-tolyl)acetamide(1610734-19-4)

Safety Data

• Hazardous Substances Data: 1610734-19-4(Hazardous Substances Data)

Upstream product

• 108-90-7 chlorobenzene 
• 685-91-6 diethylacetamide 
• 2431-96-1 N,N-diethylphenylacetamide 
• 95-46-5 2-methylphenyl bromide 
• 108-86-1 bromobenzene 

Relevant articles and documents

A general and practical palladium-catalyzed direct a-arylation of amides with aryl halides

An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong's indolebased phosphine ligand and provides monoarylated amides in up to 95% yield. Excellent chemoselectivities (>10:1) in the mono- and diarylation with aryl bromides were achieved by careful selection of bases, solvents, and stoichiometry. Under the coupling conditions, the weakly acidic α-protons of amides (pK a up to 35) were reversibly depotonated by lithium tert-butoxide (LiO-t-Bu), sodium tert-butoxide (NaO-t-Bu) or sodium bis(trimethylsilyl)amide [NaN(SiMe3)2].