1610763-24-0

Basic information

• Product Name: 2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-ol
• Synonyms: 2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-ol
• CAS NO: 1610763-24-0
• Molecular Weight: 329.398
• Mol File: 1610763-24-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-ol(1610763-24-0)
• EPA Substance Registry System: 2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-ol(1610763-24-0)

Safety Data

• Hazardous Substances Data: 1610763-24-0(Hazardous Substances Data)

Upstream product

• 1610763-22-8 1-(4-(benzyloxy)phenyl)-2-((4-(methoxymethoxy)phenyl)amino)propan-1-one 
• 4495-66-3 4-benzyloxypropiophenone 
• 100-39-0 benzyl bromide 
• 70-70-2 4-hydroxypropiophenone 
• 35081-45-9 1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone 
• 876-30-2 4-methoxymethyloxyaniline 
• 123-30-8 4-amino-phenol 
• 7107-59-7 4-(N-Benzyloxycarbonylamino)phenol 

Downstream Products

• 1610763-30-8 2-((2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)ethanol 
• 91444-54-1 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol 
• 1610763-33-1 4-(5-(2-hydroxyethoxy)-3-methyl-1H-indol-2-yl)phenol 
• 1610763-35-3 4-(5-(3-hydroxypropoxy)-3-methyl-1H-indol-2-yl)phenol 
• 1610763-26-2 3-((2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)propan-1-ol 
• 1610763-28-4 2-((2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)ethyl acetate 

Relevant articles and documents

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane x receptor antagonists

Pregnane X receptor (PXR), a member of the NR1I nuclear receptor family, acts as a xenobiotic sensor and a paramount transcriptional regulator of drug-metabolizing enzymes and transporters. The overexpression of PXR in various cancer cells indicates the importance of PXR as a drug target for countering multidrug resistance in anticancer treatments. We describe the discovery of novel bazedoxifene-scaffold-based PXR antagonists inspired by the marine sulfated steroids solomonsterol A and B as natural leads. A luciferase reporter assay on a PXR-transfected HepG2 cell line identified compounds 19-24 as promising PXR antagonists. Further structure-activity relationship studies of the most active PXR antagonist from the series (compound 20, IC50 = 11 μM) revealed the importance of hydroxyl groups as hydrogen-bond donors for PXR antagonistic activity. PXR antagonists 20 and 24 (IC50 = 14 μM), in addition to the downregulation of PXR expression, exhibited inhibition of PXR-induced CYP3A4 expression, which illustrates their potential to suppress PXR-regulated phase-I drug metabolism.