161193-44-8 Usage
Description
ErythroMycin A 9,11-IMino Ether is an intermediate compound in the synthesis of Erythromycin, a well-known macrolide antibiotic. It plays a significant role in the production process of the antibiotic, which is widely used for its broad-spectrum antibacterial properties.
Uses
Used in Pharmaceutical Industry:
ErythroMycin A 9,11-IMino Ether is used as an intermediate compound in the synthesis of Erythromycin (E649950) for its broad-spectrum antibacterial activity. This intermediate is crucial in the production process of the antibiotic, which is effective against a wide range of bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 161193-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,1,9 and 3 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 161193-44:
(8*1)+(7*6)+(6*1)+(5*1)+(4*9)+(3*3)+(2*4)+(1*4)=118
118 % 10 = 8
So 161193-44-8 is a valid CAS Registry Number.
161193-44-8Relevant articles and documents
Novel transannular rearrangements of azalide iminoethers
Wilkening, Robert R.,Ratcliffe, Ronald W.,Doss, George A.,Mosley, Ralph T.,Ball, Richard G.
, p. 16923 - 16944 (1997)
The transannular reactions between the aglycone hydroxyl groups and the iminoether and lactone groups of the 9a- and 8a-azalide iminoethers 4 and 5 were investigated under a variety of conditions. Translactonization by the 11-hydroxyl groups of 4 and 5 were found to give the corresponding 13-membered iminoethers 21 and 9. The thermal rearrangement of 4 produced an epimeric mixture of the 9,11-iminoethers 15 and 16. Further elaboration of isomer 16 produced 8-epi azithromycin 20. Finally, we have proposed an alternative structure, the amino γ-lactone 25, for one of the reported products (14) from the Beckmann rearrangement of erythromycin A (9E)-oxime 13. An authentic sample of 9a-aza-9a-homoerythromycin A 14 was prepared in three steps from iminoether 4.