161308-39-0

Basic information

• Product Name: ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT
• Synonyms: GPCP SODIUM SALT;GMPCP, SODIUM SALT;GUANOSINE-5'-[(ALPHA,BETA)-METHYLENO]DIPHOSPHATE, SODIUM SALT;ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT;A,B-methyleneguanosine 5'-diphosphate,*sodium;α,β-methyleneguanosine 5'-diphosphate sodium salt;GMPCP;GPCP
• CAS NO: 161308-39-0
• Molecular Formula: C11H15N5Na2O10P2
• Molecular Weight: 485.19
• Product Categories: Biochemicals and Reagents;Nucleosides, Nucleotides, Oligonucleotides;Nucleotide Analogs
• Mol File: 161308-39-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT(161308-39-0)
• EPA Substance Registry System: ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT(161308-39-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 161308-39-0(Hazardous Substances Data)

Usage

Description

ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT, also known as α,β-Methyleneguanosine 5′-diphosphate (GPCP; GMPCP), is a GDP methylene analog that plays a significant role in various scientific and medical applications. It is derived from the GDP molecule and has the ability to mimic its structure, allowing it to interact with different proteins and cellular processes.

Uses

Used in Research Applications:
ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT is used as a research tool for studying the self-association of tubulin, a key protein involved in the formation of microtubules. This application helps researchers understand the mechanisms behind microtubule assembly and disassembly, which are crucial for various cellular processes, including cell division and intracellular transport.
Used in Cell Biology:
ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT is used as an alternative to calcium to produce helical tubes that support bacterial division via the assembly of cytokinetic ring structures, known as Z-rings. This application aids in the study of bacterial cell division and the role of Z-rings in this process.
Used in Comparison Studies:
ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT is used as a comparative agent to the more slowly hydrolyzed analog guanylyl-(α,β)-methylene-diphosphonate (GMPCPP). This comparison helps researchers understand the differences in the behavior and stability of these two analogs, which can be crucial for the development of new drugs and therapies targeting cellular processes involving guanine nucleotides.