1613187-19-1

Basic information

• Product Name: (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide
• Synonyms: (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide
• CAS NO: 1613187-19-1
• Molecular Weight: 415.33
• Mol File: 1613187-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide(1613187-19-1)
• EPA Substance Registry System: (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide(1613187-19-1)

Safety Data

• Hazardous Substances Data: 1613187-19-1(Hazardous Substances Data)

Upstream product

• 89909-48-8 3,5-dimethyl-1H-pyrrole-2, 4-dicarboxylic acid 2-tert-butyl ester 4-benzyl ester 
• 2199-58-8 3,5-dimethylpyrrole-2-carbaldehyde 
• 37059-10-2 benzyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 

Downstream Products

• 1613187-23-7 C₄₂H₄₂N₄O₄Zn 

Relevant articles and documents

Synthesis and antimalarial activity of prodigiosenes

Several analogues of the natural compound prodigiosin with modified A- and C-rings were synthesised as were some of their tin, cobalt, boron and zinc complexes. The antimalarial activity of these prodigiosenes was evaluated in vitro using the 3D7 Plasmodium falciparum strain. The presence of a nitrogen atom in the A-ring is needed for antimalarial activity but the presence of an alkyl group at the β′-position of the C-ring seems detrimental. Dibutyl tin complexes exhibit IC50 values mostly in the nanomolar range with equal or improved activity compared to the free-base prodigiosene ligand, despite the fact that the general toxicity of such tin complexes is demonstrably lower than that of the free-bases. This journal is the Partner Organisations 2014.