1613234-48-2

Basic information

• Product Name: C₅₉H₄₇IrN₂O₄P₂
• Synonyms: C₅₉H₄₇IrN₂O₄P₂
• CAS NO: 1613234-48-2
• Molecular Weight: 1102.2
• Mol File: 1613234-48-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₅₉H₄₇IrN₂O₄P₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₉H₄₇IrN₂O₄P₂(1613234-48-2)
• EPA Substance Registry System: C₅₉H₄₇IrN₂O₄P₂(1613234-48-2)

Safety Data

• Hazardous Substances Data: 1613234-48-2(Hazardous Substances Data)

Upstream product

• 12112-67-3 bis(1,5-cyclooctadiene)diiridium(I) dichloride 
• 591-87-7 Allyl acetate 
• 153775-42-9 2-nitro-4-carboxybenzonitrile 
• 99646-28-3 1,1′-binaphthalene-2,2′-diylbis[bis(4-methylphenyl)phosphine] 
• 99646-28-3 (R)-tol-BINAP 

Relevant articles and documents

Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C?C Bond-Forming Transfer Hydrogenation

Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C?C coupling of primary alcohols and isoprene oxide. Based on this methodology, an oxetane containing analogue of haloperidol was prepared. A related azetidine formation is also described.

Redox-triggered C-c coupling of alcohols and vinyl epoxides: Diastereo- and enantioselective formation of all-carbon quaternary centers via tert -(Hydroxy)-prenylation

Iridium catalyzed primary alcohol oxidation triggers reductive C-O bond cleavage of isoprene oxide to form aldehyde-allyliridium pairs that combine to form products of tert-(hydroxy)-prenylation, a motif found in >2000 terpenoid natural products. Curtin-Hammett effects are exploited to enforce high levels of anti-diastereo- and enantioselectivity in the formation of an all-carbon quaternary center. The present redox-triggered carbonyl additions occur in the absence of stoichiometric byproducts, premetalated reagents, and discrete alcohol-to-aldehyde redox manipulations.