1613376-41-2

Basic information

• Product Name: 2-((3R,5R)-2-benzyloxycarbonyl-5-(chloromethyl)isoxazolidinyl)acetic acid
• Synonyms: 2-((3R,5R)-2-benzyloxycarbonyl-5-(chloromethyl)isoxazolidinyl)acetic acid
• CAS NO: 1613376-41-2
• Molecular Weight: 496.523
• Mol File: 1613376-41-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((3R,5R)-2-benzyloxycarbonyl-5-(chloromethyl)isoxazolidinyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((3R,5R)-2-benzyloxycarbonyl-5-(chloromethyl)isoxazolidinyl)acetic acid(1613376-41-2)
• EPA Substance Registry System: 2-((3R,5R)-2-benzyloxycarbonyl-5-(chloromethyl)isoxazolidinyl)acetic acid(1613376-41-2)

Safety Data

• Hazardous Substances Data: 1613376-41-2(Hazardous Substances Data)

Upstream product

• 1628118-80-8 C₁₄H₁₅Cl₂NO₄ 
• 1613376-40-1 (3R,5R)-benzyl 3-(2-(2-(2-(benzyloxy)-2-oxoethyl)-2-methylhydrazinyl)-2-oxoethyl)-5-(chloromethyl)isoxazolidine-2-carboxylate 
• 1613376-39-8 2-((3R,5R)-2-benzyloxycarbonyl-5-(chloromethyl)isoxazolidinyl)acetic acid 
• 1613376-37-6 (3S,5R)-3-allyl-2-benzyloxycarbonyl-5-chloromethylisoxazolidine 
• 1613376-35-4 (R)-benzyl (1-chloropent-4-en-2-yl)oxycarbamate 

Downstream Products

• 33404-78-3 negamycin 

Relevant articles and documents

A total synthesis of (+)-negamycin through isoxazolidine allylation

The β-amino acid antibiotic (+)-negamycin has been synthesised in ten steps from epichlorohydrin via Sakurai allylation of an isoxazolidine intermediate. The key allylation reaction proceeded with complete trans-selectivity, which is attributed to electrostatic attraction between the chlorine atom and the iminium ion in the Sakurai intermediate. This journal is the Partner Organisations 2014.