1613704-80-5Relevant articles and documents
benzyl ethylene acrylic farnesyl thiophosphoro salicylic acid derivatives and its preparation and use
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Paragraph 0105; 0119; 0120, (2017/01/23)
The invention discloses a phenyl acrylic acid farnesyl thiosalicylic acid (FTA) derivative as well as a preparation method and an application. The phenyl acrylic acid farnesyl thiosalicylic acid derivative is a compound of a formula (I) in the specification, wherein X1 represents O or NH; X2 represents O or NH; n is equal to 1- 3; R represents H or OCH3. By coupling ferulic acid and p-hydroxy cinnamic acid fragments with carboxyl of FTA, the capability of a target molecule in scavenging free radicals is improved, the anti-tumor effect of the molecule is improved, and then a compound with anti-tumor activity or anti-inflammatory activity higher than those of FTA is obtained.