1613704-84-9

Basic information

• Product Name: 4-((E)-3-(4-(4-methylpiperazin-1-yl)butoxy)-3-oxoprop-1-enyl)-phenyl-2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoate
• Synonyms: 4-((E)-3-(4-(4-methylpiperazin-1-yl)butoxy)-3-oxoprop-1-enyl)-phenyl-2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoate
• CAS NO: 1613704-84-9
• Molecular Weight: 658.946
• Mol File: 1613704-84-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((E)-3-(4-(4-methylpiperazin-1-yl)butoxy)-3-oxoprop-1-enyl)-phenyl-2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((E)-3-(4-(4-methylpiperazin-1-yl)butoxy)-3-oxoprop-1-enyl)-phenyl-2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoate(1613704-84-9)
• EPA Substance Registry System: 4-((E)-3-(4-(4-methylpiperazin-1-yl)butoxy)-3-oxoprop-1-enyl)-phenyl-2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoate(1613704-84-9)

Safety Data

• Hazardous Substances Data: 1613704-84-9(Hazardous Substances Data)

Upstream product

• 1613704-69-0 C₁₈H₂₆N₂O₃ 
• 162520-00-5 salirasib 

Relevant articles and documents

Synthesis and biological evaluation of hybrids from farnesylthiosalicylic acid and hydroxylcinnamic acid with dual inhibitory activities of Ras-related signaling and phosphorylated NF-κB

A series of hybrids (5a-r) of farnesylthiosalicylic acid (FTS) and hydroxylcinnamic acid were designed and synthesized. Most of the hybrids displayed potent antiproliferative activity against seven cancer cell lines in vitro, superior to FTS as well as sorafenib. The most potent compound 5f selectively inhibited cancer cells but not non-tumor liver cell proliferation in vitro, and significantly induced SMMC-7721 cell apoptosis. Interestingly, 5f could simultaneously inhibit not only Ras-related signaling but also phosphorylated NF-κB, which may synergetically contribute to the cell growth inhibition and apoptosis induction. Moreover, 5f showed low acute toxicity to mice and significantly inhibited the hepatoma tumor growth. the Partner Organisations 2014.