161496-59-9

Basic information

• Product Name: N-methyl-O-methyl-D-tyrosine methyl ester
• Synonyms: N-methyl-O-methyl-D-tyrosine methyl ester
• CAS NO: 161496-59-9
• Molecular Weight: 223.272
• Mol File: 161496-59-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-methyl-O-methyl-D-tyrosine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-O-methyl-D-tyrosine methyl ester(161496-59-9)
• EPA Substance Registry System: N-methyl-O-methyl-D-tyrosine methyl ester(161496-59-9)

Safety Data

• Hazardous Substances Data: 161496-59-9(Hazardous Substances Data)

Upstream product

• 3728-20-9 D-tyrosine methylester hydrochloride 
• 76757-90-9 N-(tert-butoxycarbonyl)-D-tyrosine methyl ester 
• 556-02-5 tyrosine 
• 339183-16-3 (R)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 161496-58-8 N-^tBOC-N-methyl-O-methyl-D-tyrosine methyl ester 

Downstream Products

• 200504-93-4 N-^tBOC-L-alanyl-N-methyl-O-methyl-3-bromo-D-tyrosyl-L-alanine methyl ester 
• 200504-92-3 N-^tBOC-L-alanyl-N-methyl-O-methyl-D-tyrosyl-L-alanine methyl ester 
• 339183-18-5 (R)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid 
• 339183-17-4 (R)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 200504-91-2 N-BOC-L-alanyl-N-methyl-O-methyl-D-tyrosine methyl ester 

Relevant articles and documents

Synthetic studies of a didemnin B analog based on a 2,3-diamino sugar scaffolding

Reductive amination, amide formation using BOP [(1H-1,2,3-benzotriazol-1-yloxy)tris(dimethyl-amino)-phosphonium hexafluorophosphate] and esterification via DCC (dicyclohexylcarbodiimide) were the key synthetic steps to generate an advanced intermediate in the preparation of a didemnin B analog based on a sugar scaffolding (2). This analog should provide insight into the bioactive conformation of didemnin B.

A highly efficient method of N-methylation for the amino acid derivatives

Many naturally occurring, biologically active cyclic peptides are found to contain several N-methyl amino acid constituents.A method has been found out for the N-methylation of amino acid derivatives using sodium hexamethyl disilazide and methyl iodide which gives very good yield without the racemisation.