161535-70-2

Basic information

• Product Name: 2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione
• CAS NO: 161535-70-2
• Molecular Formula: C₁₆H₁₂N₂O₄
• Molecular Weight: 296.27748
• Mol File: 161535-70-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione(161535-70-2)
• EPA Substance Registry System: 2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione(161535-70-2)

Safety Data

• Hazardous Substances Data: 161535-70-2(Hazardous Substances Data)

Upstream product

• 610-27-5 4-nitrophthalic acid 
• 19241-16-8 2,6-dimethylphenylisothiocyanate 
• 5466-84-2 4-nitrophthalic anhydride 
• 87-62-7 2,6-dimethylaniline 

Downstream Products

• 1059734-06-3 2-(2,6-dimethylphenyl)-5-[(4-phenylquinazolin-2-yl)amino]-1H-isoindole-1,3(2H)-dione 
• 158276-70-1 4-amino-N-(2,6-dimethylphenyl)phthalimide 

Relevant articles and documents

Mechanochemical synthesis of phthalimides with crystal structures of intermediates and products

A series of phthalimides have been successfully synthesized in the solid state by grinding (or kneading) of substituted phthalic anhydride and aniline derivatives. Selected products and intermediates were crystallized and characterized by crystallography leading to a potential rationale for the solid-state reactivity that suggests that co-crystals could serve as intermediates. This journal is

Design, anticonvulsive and neurotoxic properties of retrobenzamides / N- (nitrophenyl)benzamides and N-(aminophenyl)benzamides

Design, anticonvulsant properties in maximal electroshock-reduced seizures [MES] and seizures reduced by subcutaneous administration of pentetrazole (scPtz), and neurotoxicity of retrobenzamides (N- (nitrophenyl)benzamides and N-(aminophenyl) benzamides are reported. These data are further compared with those on carbamazepine, phenytoin, ameltolide and other reference compounds. Studies on retrobenzamides in mice dosed intraperitoneally point out a good anticonvulsant potential in the MES test for the amino derivatives (N-(aminophenyl)benzamides) and moderate activity for corresponding 'nitro' derivatives. In rats dosed orally, aminoretrobenzamides were, however, less active in the MES test than in mice dosed intraperitoneally. Differences between experimental animal species and administration routes lead to hypothesize rapid metabolization of compounds, reduced intestinal resorption and increased removal from body. The presence of a methyl substitution on the N-phenyl moiety of aminoretrobenzamides attenuated these discrepancies between mice and rats. Present results indicate that pharmacological values - including the dose offering anticonvulsant protection in 50 % of tested animals (ED50) and protective indices - obtained on some retrobenzamides may compete with phenytoin and carbamazepine values. By contrast with phenytoin, some retrobenzamides further exhibit activity in the scPtz test.

REACTION OF ARYL ISOTHIOCYANATES WITH PHTHALIC ACID DERIVATIVES

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