161617-96-5Relevant articles and documents
Synthesis of (+/-) - oxohexahydrofuro[3,2-b]pyrroles (pyrrolidine-trans-lactones) via a reduction - Alkylation protocol
Macdonald, Simon J.F.,Montana, John G.,Buckley, Doreen M.,Dowle, Michael D.
, p. 1378 - 1380 (1998)
A synthesis of pyrrolidine-trans-lactones is described commencing from 1-(benzyloxycarbonyl)-3-oxo-2-pyrrolidineacetic acid ethyl ester. cis-Reduction of the oxo-pyrrolidine followed by hydroxyl inversion with benzoic acid in a Mitsunobu reaction gave the trans-benzoate ester which was converted into its corresponding silyl ether. After allylation α to ethyl ester, silyl deprotection, saponification and trans-lactonisation gave pyrrolidine-trans-lactones. Stereoselective allylation of trans-1-(benzyloxycarbonyl)- 3-hydroxy-2-pyrrolidine-acetic acid ethyl ester is feasible to give predominantly the desired diastereomer.
Pyrazolopyridine adenosine antagonists
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Page column 31, (2008/06/13)
The present invention relates to a novel pyrazolopyridine compound of the following formula: whereinR1 is aryl, andR2 is cyclo(lower)alkyl which may have one or more suitable substituent(s), etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said pyrazolopyridine compound or a salt thereof; a pharmaceutical composition comprising said pyrazolopyridine compound or a pharmaceutically acceptable salt thereof; etc.
