1616289-34-9

Basic information

• Product Name: 5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 1616289-34-9
• Molecular Weight: 216.067
• Mol File: 1616289-34-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one(1616289-34-9)
• EPA Substance Registry System: 5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one(1616289-34-9)

Safety Data

• Hazardous Substances Data: 1616289-34-9(Hazardous Substances Data)

Usage

General Description

5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one is a chemical compound that belongs to the class of isoquinolinones. It is a derivative of isoquinoline and contains two chlorine atoms at positions 5 and 8 on the isoquinoline ring. 5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one has potential pharmacological properties and has been studied for its use in drug development. It may have applications in the field of medicinal chemistry, particularly in the development of novel pharmaceuticals. Its structure and properties make it a promising candidate for further research and potential therapeutic use.

Upstream product

• 3218-50-6 2-(2,5-dichlorophenyl)acetonitrile 
• 1616289-32-7 ethyl 3,6-dichloro-2-(cyanomethyl)benzoate 
• 1616289-30-5 ethyl 3,6-dichloro-2-methyl-benzoate 
• 7499-08-3 3-chloro-2-methylbenzoic acid 
• 1616289-31-6 ethyl 2-(bromomethyl)-3,6-dichloro-benzoate 
• 1918-01-0 3,6-dichloro-2-methyl-benzoic acid 

Downstream Products

• 1616289-35-0 7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one 
• 1616287-82-1 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one 
• 1616289-37-2 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1616289-36-1 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one 
• 1616289-39-4 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

EZH2 Inhibitors

The present invention relates to compounds that inhibit EZH2 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

ARYL FUSED LACTAMS AS EZH2 MODULATORS

This invention relates to compounds of Formula (I) in which R1, R2, R3, R4, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

ARYL AND HETEROARYL FUSED LACTAMS

This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.