1616393-06-6

Basic information

• Product Name: N-(3-amino-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide
• Synonyms: N-(3-amino-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide
• CAS NO: 1616393-06-6
• Molecular Weight: 373.498
• Mol File: 1616393-06-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-amino-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-amino-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide(1616393-06-6)
• EPA Substance Registry System: N-(3-amino-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide(1616393-06-6)

Safety Data

• Hazardous Substances Data: 1616393-06-6(Hazardous Substances Data)

Upstream product

• 1616474-08-8 N-(3-(2-diazoacetyl)-5-nitrophenyl)pyrrolidine-1-carboxamide 
• 1616474-07-7 3-nitro-5-(pyrrolidine-1-carboxamido)benzoic acid 
• 1616474-06-6 ethyl 3-nitro-5-(pyrrolidine-1-carboxamido)benzoate 
• 10394-67-9 ethyl 3-amino-5-nitrobenzoate 
• 618-84-8 3-amino-5-nitro-benzoic acid 
• 99-34-3 3,5-dinitrobenzoic acid 

Downstream Products

• 1616474-16-8 N-(3-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)-5-((4-(3-(pyridin-3-ylmethoxy)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide 
• 1616474-26-0 N-(3-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)-5-((4-(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide 
• 1616393-10-2 N-(3-((1-(4-methoxybenzyl)-2-oxo-6-ureido-1,2-dihydroquinolin-3-yl)amino)-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide 

Relevant articles and documents

Synthesis and biological evaluation of substituted 2-anilino-7H- pyrrolopyrimidines as PDK1 inhibitors

An efficient and scalable route for a series of novel substituted 2-anilino-7H-pyrrolopyrimidine compounds as potential inhibitors of PDK1, an important regulator of the PI3K/Akt pathway that is dysregulated in many cancers, was developed and is described. The synthetic strategy was designed around Suzuki and Buchwald-Hartwig cross-couplings of a boronate fragment and various customised anilines sequentially with 2,4-dichloro-7-tosyl-7H- pyrrolopyrimidine. All fragments were constructed separately and cross-coupled to provide access to a range of novel compounds. Biological evaluation of these was undertaken, with modest inhibition observed.