161670-78-6

Basic information

• Product Name: 4-hydroxy-1-methyl-4-pentafluoroethyl-2-phenyl-4,5-dihydroimidazole
• Synonyms: 4-hydroxy-1-methyl-4-pentafluoroethyl-2-phenyl-4,5-dihydroimidazole
• CAS NO: 161670-78-6
• Molecular Weight: 294.224
• Mol File: 161670-78-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-1-methyl-4-pentafluoroethyl-2-phenyl-4,5-dihydroimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-1-methyl-4-pentafluoroethyl-2-phenyl-4,5-dihydroimidazole(161670-78-6)
• EPA Substance Registry System: 4-hydroxy-1-methyl-4-pentafluoroethyl-2-phenyl-4,5-dihydroimidazole(161670-78-6)

Safety Data

• Hazardous Substances Data: 161670-78-6(Hazardous Substances Data)

Upstream product

• 6313-33-3 formamidine hydrochloride 
• 2568-34-5 N-benzoyl-N-methylglycine 
• 356-42-3 2,2,3,3,3-pentafluoropropanoic anhydride 

Relevant articles and documents

AN EFFICIENT SYNTHESIS OF 4-TRIFLUOROMETHYLATED AND 4-PERFLUOROALKYLATED IMIDAZOLES FROM MESOIONIC 1,3-OXAZOLIUM-5-OLATES

4-Trifluoromethyl- and 4-perfluoroalkylimidazoles (4) were conveniently synthesized from mesoionic 4-trifluoroacetyl- or 4-perfluoroacyl-1,3-oxazolium-5-olate (1) via 2-imidazolines (3), which were formed through the regioselective attack of ammonia on the C(2) position of 1.

Convenient synthesis of 5-trifluoroacetylated imidazoles by ring transformation of mesoionic 1,3-oxazolium-5-olates

Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1), obtained from the reaction of N-acyl-N-alkylglycines (2) with trifluoroacetic anhydride, react with amidines to give 5-trifluoroacetylimidazoles (3) in moderate yield. The novel ring transformations of 1 into 3 occur via an initial attack of amidines on the C-2 position of the ring.