1616761-00-2 Usage
Description
3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers at the 3R and 4R positions, which contribute to its stereochemistry. The molecule contains a 2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl group, a methylamino group, and a 3-oxopropanenitrile moiety, which are all connected through a 4-methylpiperidin-1-yl bridge. 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile is an impurity found in Tasocitinib (Tofacitinib [T528000]), a drug used for the treatment of certain inflammatory conditions.
Uses
1. Pharmaceutical Industry:
3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile is used as an impurity in the synthesis and production of Tasocitinib (Tofacitinib [T528000]). Its presence is crucial for the quality control and safety assessment of the drug, as impurities can affect the drug's efficacy, safety, and stability.
2. Research and Development:
3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile can be used as a research tool in the development of new drugs targeting inflammatory conditions. By studying its structure and properties, researchers can gain insights into the design and synthesis of novel therapeutic agents with improved efficacy and safety profiles.
3. Quality Control and Analytical Chemistry:
3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile can be employed as a reference material in the development and validation of analytical methods for the quantification and identification of impurities in pharmaceutical products. This is essential for ensuring the quality, safety, and efficacy of the drugs being used by patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1616761-00-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,6,7,6 and 1 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1616761-00:
(9*1)+(8*6)+(7*1)+(6*6)+(5*7)+(4*6)+(3*1)+(2*0)+(1*0)=162
162 % 10 = 2
So 1616761-00-2 is a valid CAS Registry Number.
1616761-00-2Relevant articles and documents
Tropsch process for cloth intermediate impurity, tofa for cloth impurity and its synthesis method, and Tropsch process for the cloth quality monitoring method
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Paragraph 0077-0079; 0082; 0085, (2017/08/26)
The invention provides a tofacitinib intermediate impurity, tofacitinib impurity and a synthetic method, and a tofacitinib quality monitoring method. The tofacitinib intermediate impurity has a chemical formula in a formula (I), and the tofacitinib impurity has a chemical formula in a formula (II). Through the provided tofacitinib intermediate impurity and the tofacitinib impurity, the invention provides a standard contrast product for monitoring and optimizing quality of N-methyl-N-((3R,4R)-4-methyl piperidine-3-group)-7H-pyrrolo[2,3-D]pyrimidine-4-amine (tofacitinib), and then performs qualitative and quantitative analysis on the tofacitinib intermediate and tofacitinib.
