1616849-94-5

Basic information

• Product Name: ZAsp(CH₃)NPr
• Synonyms: ZAsp(CH₃)NPr
• CAS NO: 1616849-94-5
• Molecular Weight: 322.361
• Mol File: 1616849-94-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ZAsp(CH₃)NPr(CAS DataBase Reference)
• NIST Chemistry Reference: ZAsp(CH₃)NPr(1616849-94-5)
• EPA Substance Registry System: ZAsp(CH₃)NPr(1616849-94-5)

Safety Data

• Hazardous Substances Data: 1616849-94-5(Hazardous Substances Data)

Upstream product

• 1616849-90-1 C₂₀H₃₀N₂O₅ 
• 3338-32-7 Z-Asp(OtBu)-OSu 

Relevant articles and documents

Mechanistic insight into the lability of the benzyloxycarbonyl (Z) group in N-protected peptides under mild basic conditions

An unexpected lability of the benzyloxycarbonyl (Z) protecting group under mild basic conditions at room temperature is explained by a mechanism based on anchimeric assistance. It is found that the vicinal amide group stabilises the tetrahedral intermediate formed after nucleophilic addition of hydroxide to the carbonyl of the Z group. This effect operates in N-protected tripeptides and tetrapeptides but Z-protected dipeptides are stable under the same conditions due to blockage of the vicinal amide NH by intramolecular H-bonding with the terminal carboxylate moiety. Copyright