16172-03-5 Usage
Description
OXOLINIC ACID IMPURITY B is a potentially harmful chemical impurity found in pharmaceutical products containing oxolinic acid. It is crucial to monitor its levels in drug formulations, as excessive amounts can pose a risk to human health. This impurity may be generated as a byproduct during the manufacturing process of oxolinic acid or may be present as a contaminant in raw materials. Strict quality control measures are essential to ensure the safety and efficacy of oxolinic acid-containing medications.
Uses
As OXOLINIC ACID IMPURITY B is a harmful impurity, its primary use is in the context of quality control and safety monitoring in the pharmaceutical industry. It is not intended for direct application in any therapeutic or industrial process.
Used in Pharmaceutical Industry:
OXOLINIC ACID IMPURITY B is used as a quality control parameter for ensuring the safety and efficacy of oxolinic acid-containing medications. It is monitored and controlled to adhere to the maximum limits established by regulatory agencies such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) to safeguard public health.
Check Digit Verification of cas no
The CAS Registry Mumber 16172-03-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,1,7 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16172-03:
(7*1)+(6*6)+(5*1)+(4*7)+(3*2)+(2*0)+(1*3)=85
85 % 10 = 5
So 16172-03-5 is a valid CAS Registry Number.
16172-03-5Relevant articles and documents
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Kaminsky,Meltzer
, p. 160,163,175,163 (1968)
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Synthesis of 5-ethyl-8-oxo-5.8-dihydro-1,3-dioxolo [4,5-g] quinolines and related compounds
Pednekar, Suhas,Pandey, Anil Kumar
scheme or table, p. 357 - 360 (2011/12/16)
Condensation of N-ethyl-3,4-methylenedioxyaniline 1 with diethyl ethoxymethylenemalonate 2 gave the unsaturated ester 3 which on thermal cyclization in refluxing diphenyl oxide gave ester 4. The ester on basic hydrolysis formed free acid 5 which upon treatment with thionyl chloride gave the acid chloride 6. Treatment of 6 with o-phenylenediamine, hydrazine hydrate, ammonia, urea and thiourea gave the amides (7-11). CS2 treatment in presence of KOH on 8 gave 12. 7-12 were prepared by conventional as well as under microwave irradiation. These compounds have been characterized on the basis of elemental analysis, IR, NMR and MS data.
N-alkylation of ethyl 1,4-dihydro-4-oxopyridine-3-carboxylates via their thallium(I) salts
Tamura,Fujita,Chen,et al.
, p. 739 - 743 (2007/10/02)
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