161832-64-0

Basic information

• Product Name: (R)-7-acetyl-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]-benzodiazepine
• Synonyms: (R)-7-acetyl-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]-benzodiazepine
• CAS NO: 161832-64-0
• Molecular Weight: 367.361
• Mol File: 161832-64-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-7-acetyl-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]-benzodiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-7-acetyl-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]-benzodiazepine(161832-64-0)
• EPA Substance Registry System: (R)-7-acetyl-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]-benzodiazepine(161832-64-0)

Safety Data

• Hazardous Substances Data: 161832-64-0(Hazardous Substances Data)

Upstream product

• 94-59-7 1-allyl-3,4-methylenedioxybenzene 
• 4676-39-5 1-(1,3-benzodioxol-5-yl)-2-propanone 
• 196303-01-2 isochroman 
• 172542-26-6 (S)-α-methyl-1,3-benzodioxole-5-ethanol 
• 196303-03-4 (S)-acetic acid-[[6-(2-hydroxypropyl)-1,3-benzodioxol-5-yl](4-nitrophenyl)methylene]hydrazide 
• 196303-02-3 (5RS,7S)-7,8-dihydro-7-methyl-5-(4-nitrophenyl)-5H-1,3-dioxolo[4,5-G][2]benzopyran-5-ol 
• 176777-96-1 (S)-acetic acid[[6-[2-[(methylsulfonyl)oxy]propyl]-1,3-benzodioxol-5-yl](4-nitrophenyl)methylene]hydrazide 

Downstream Products

• 161832-65-1 (8R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine 

Relevant articles and documents

Application of a practical biocatalytic reduction to an enantioselective synthesis of the 5H-2,3-benzodiazepine LY300164

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Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazepine AMPA antagonists

A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists.