1618648-59-1

Basic information

• Product Name: N-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-yl)methyl)-2,2,2-trifluoro-N-(2-(methylsulfonyl)ethyl)acetamide
• Synonyms: N-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-yl)methyl)-2,2,2-trifluoro-N-(2-(methylsulfonyl)ethyl)acetamide
• CAS NO: 1618648-59-1
• Molecular Weight: 677.076
• Mol File: 1618648-59-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 813.1±65.0 °C(Predicted)
• Density: 1.454±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-yl)methyl)-2,2,2-trifluoro-N-(2-(methylsulfonyl)ethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-yl)methyl)-2,2,2-trifluoro-N-(2-(methylsulfonyl)ethyl)acetamide(1618648-59-1)
• EPA Substance Registry System: N-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-yl)methyl)-2,2,2-trifluoro-N-(2-(methylsulfonyl)ethyl)acetamide(1618648-59-1)

Safety Data

• Hazardous Substances Data: 1618648-59-1(Hazardous Substances Data)

Upstream product

• 17329-31-6 6-amino-4-hydroxyquinazoline 
• 6943-17-5 6-nitroquinazolin-4-ol 
• 17420-30-3 5-nitroanthranilonitrile 
• 1618648-60-4 2,2,2,-trifluoro-N-[2-(methylsulphonyl)ethyl]-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl) acetamide 
• 1618648-57-9 2,2,2-trifluoro-N-{[5-(4-hydroxyquinazolin-6-yl)furan-2-yl]methyl}-N-[2-(methylsulphonyl)ethyl]acetamide 
• 1334953-74-0 6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-ol 
• 1383531-71-2 2-(methylsulphonyl)-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl)ethanamine 
• 1383531-70-1 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde 
• 16064-08-7 6-iodo-4-hydroxyquinazoline 
• 1383531-69-8 6-iodo-4-(tetrahydro-2H-pyran-2-yloxy)quinazoline 
• 1618648-58-0 N-{[5-(4-chloroquinazolin-6-yl)furan-2-yl]methyl}-2,2,2-trifluoro-N-[2-(methylsulphonyl)ethyl]acetamide 
• 202197-26-0 3-chloro-4-(3-fluorobenzyloxy)aniline 

Downstream Products

• 231277-92-2 lapatanib 
• 388082-78-8 lapatinib ditosylate 

Relevant articles and documents

EFFICIENT PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES

The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.

Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates

The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.