161884-93-1

Basic information

• Product Name: (1-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-oxo-ethyl}-cyclohexyl)-acetic acid
• Synonyms: (1-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-oxo-ethyl}-cyclohexyl)-acetic acid
• CAS NO: 161884-93-1
• Molecular Weight: 402.466
• Mol File: 161884-93-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-oxo-ethyl}-cyclohexyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-oxo-ethyl}-cyclohexyl)-acetic acid(161884-93-1)
• EPA Substance Registry System: (1-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-2-oxo-ethyl}-cyclohexyl)-acetic acid(161884-93-1)

Safety Data

• Hazardous Substances Data: 161884-93-1(Hazardous Substances Data)

Upstream product

• 1010-26-0 1,1-cyclohexanediacetic acid anhydride 
• 84163-13-3 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride 

Downstream Products

• 161884-94-2 4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-(5-hydroxy-3,3-pentamethylenepent-1-yl)piperidine 

Relevant articles and documents

Mesolimbic selective antipsychotic arylcarbamates

4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidine has been linked to various arylcarbamates to obtain compounds having affinity for dopamine-D1 and -D2, serotonin 5HT(2A) and α1-adrenoceptors. When linkers with restricted flexibility are used, the biological activity is reduced indicating that a bended conformation is needed in this series of bioactive molecules. Compounds with a relatively low D2/5HT(2A) affinity ratio in receptor binding experiments and high affinity for the α1-adrenoceptors exhibit a pharmacological profile which suggests a preferential effect on the mesocorticolimbic dopaminergic system and an 'atypical' antipsychotic activity.