161988-96-1Relevant articles and documents
Chiral acetylenic sulfoxides in organic synthesis: Secondary amine cyclization and total synthesis of (S)-(-)-carnegine
Chan, Winghong,Lee, Albert W. M.,Jiang, Lasheng
, p. 715 - 718 (2007/10/02)
Michael addition of secondary amines 1b-1g onto chiral acetylenic sulfoxides 2 followed by acid induced cyclization afforded structures of tetrahydroisoquinoline skeleton in high to moderate diastereoselectivity. Optical pure (S)-(-)-carnegine has been sy