1620061-40-6

Basic information

• Product Name: (4-phenylbutan-2-yl)(trifluoromethyl)sulfane
• Synonyms: (4-phenylbutan-2-yl)(trifluoromethyl)sulfane
• CAS NO: 1620061-40-6
• Molecular Weight: 234.285
• Mol File: 1620061-40-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (4-phenylbutan-2-yl)(trifluoromethyl)sulfane(CAS DataBase Reference)
• NIST Chemistry Reference: (4-phenylbutan-2-yl)(trifluoromethyl)sulfane(1620061-40-6)
• EPA Substance Registry System: (4-phenylbutan-2-yl)(trifluoromethyl)sulfane(1620061-40-6)

Safety Data

• Hazardous Substances Data: 1620061-40-6(Hazardous Substances Data)

Upstream product

• 143097-80-7 2-bromo-4-phenylbutane 
• 2344-70-9 1-phenyl-3-butanol 
• 811-68-7 silver(I) trifluoromethanethiolate 
• 1417800-60-2 (3-thiocyanatobutyl)benzene 
• 77152-08-0 trifluoromethylcopper(I) 
• 116199-39-4 4-phenylbutan-2-yl 4-methylbenzene-1-sulfonate 

Relevant articles and documents

Dehydroxylative Trifluoromethylthiolation, Trifluoromethylation, and Difluoromethylation of Alcohols

CF3S, CF3 and HCF2 groups have been identified as valuable functionalities for drug development. Despite significant accomplishments in the trifluoromethylthiolation, trifluoromethylation and difluoromethylation reactions, directly converting common functional groups into CF3S, CF3 or HCF2 groups is still highly desirable. Described here is the dehydroxylative trifluoromethylthiolation, trifluoromethylation and difluoromethylation of alcohols promoted by a R3P/ICH2CH2I system. All of these dehydroxylative reactions were achieved under mild conditions via the activation of the hydroxyl group by the R3P/ICH2CH2I system. A wide substrate scope and good functional group tolerance were observed.

Deoxytrifluoromethylthiolation and Selenylation of Alcohols by Using Benzothiazolium Reagents

Aliphatic compounds substituted with medicinally important trifluoromethylthio (SCF3) and trifluoromethylselenyl (SeCF3) groups were synthesized directly from alcohols by using the new benzothiazolium salts BT-SCF3 and BT-SeCF3. These bench-stable fluorine-containing reagents are facile to use and can be prepared in two steps from non-fluorinated heteroaromatic starting materials. The metal-free deoxytrifluoromethylthiolation process using BT-SCF3 proceeds under mild conditions and the similarly efficient trifluoromethylselenylation reactions using BT-SeCF3 are, to the best of our knowledge, the first reported examples of this transformation.

Direct dehydroxytrifluoromethylthiolation of alcohols using silver(I) trifluoromethanethiolate and tetra-n-butylammonium iodide

An unprecedented reaction for the direct trifluoromethylthiolation and fluorination of alkyl alcohols using AgSCF3 and nBu4NI has been developed. The trifluoromethylthiolated compounds and alkyl fluorides were selectively formed by c