1620068-98-5

Basic information

• Product Name: C₂₉H₃₀F₃N₇O₃
• CAS NO: 1620068-98-5
• Molecular Weight: 581.598
• Mol File: 1620068-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₀F₃N₇O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₀F₃N₇O₃(1620068-98-5)
• EPA Substance Registry System: C₂₉H₃₀F₃N₇O₃(1620068-98-5)

Safety Data

• Hazardous Substances Data: 1620068-98-5(Hazardous Substances Data)

Upstream product

• 677704-58-4 4-(morpholin-4-yl)-3-(trifluoromethyl)benzoic acid 
• 1620069-22-8 (S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol 
• 1620069-21-7 (S)-1-(4-(2-(3-nitrobenzyl)-1H-imidazole-1-yl)pyrimidin-2-ylamino)propan-2-ol 
• 1620069-20-6 2-(methylsulfonyl)-4-(2-(3-nitrobenzyl)-1H-imidazol-1-yl)pyrimidine 
• 1620069-19-3 2-(methylthio)-4-(2-(3-nitrobenzyl)-1H-imidazol-1-yl)pyrimidine 
• 1523027-75-9 2-(3-nitrobenzyl)-1H-imidazole 
• 1620069-18-2 N-(2,2-dimethoxyethyl)-2-(3-nitrophenyl)acetimidamide 
• 621-50-1 (3-nitrophenyl)acetonitrile 

Relevant articles and documents

Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors

The synthesis of a novel series of (4-aminobenzyl/benzoyl)-1H-imidazol-1-yl pyrimidin-2-yl derivatives 9, 10, 18, 19 and their in vitro antiproliferative activities against the A375P human melanoma cell line and the U937 human leukemic monocyte lymphoma cell line are described. Potent antiproliferative effects were found from 9l, 9s and 10c; 10c was found to be a highly potent and selective BRAF V600E and CRAF inhibitor (IC50 = 38.3 nM and 8.79 nM).