1620134-57-7

Basic information

• Product Name: 3'-bromo-4-biphenylmethylamine hydrochloride
• CAS NO: 1620134-57-7
• Molecular Weight: 298.61
• Mol File: 1620134-57-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3'-bromo-4-biphenylmethylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-bromo-4-biphenylmethylamine hydrochloride(1620134-57-7)
• EPA Substance Registry System: 3'-bromo-4-biphenylmethylamine hydrochloride(1620134-57-7)

Safety Data

• Hazardous Substances Data: 1620134-57-7(Hazardous Substances Data)

Upstream product

• 108-36-1 1,3-dibromobenzene 

Relevant articles and documents

Substituted N -(biphenyl-4′-yl)methyl (R)-2-acetamido-3- methoxypropionamides: Potent anticonvulsants that affect frequency (Use) dependence and slow inactivation of sodium channels

We prepared 13 derivatives of N-(biphenyl-4′-yl)methyl (R)-2-acetamido-3-methoxypropionamide that differed in type and placement of a R-substituent in the terminal aryl unit. We demonstrated that the R-substituent impacted the compound's whole animal and cellular pharmacological activities. In rodents, select compounds exhibited excellent anticonvulsant activities and protective indices (PI = TD50/ED50) that compared favorably with clinical antiseizure drugs. Compounds with a polar, aprotic R-substituent potently promoted Na+ channel slow inactivation and displayed frequency (use) inhibition of Na+ currents at low micromolar concentrations. The possible advantage of affecting these two pathways to decrease neurological hyperexcitability is discussed.