16204-37-8Relevant articles and documents
One-pot synthesis of non-symmetric tetraoxanes with the H2O2/MTO/fluorous alcohol system
Iskra, Jernej,Bonnet-Delpon, Danièle,Bégué, Jean-Pierre
, p. 6309 - 6312 (2003)
1,2,4,5-Tetraoxanes, potent antimalarial drugs, were selectively synthesized in fluorous alcohols (2,2,2-trifluoroethanol-TFE and 1,1,1,3,3,3-hexafluoro-2-propanol-HFIP). A use of these solvents enabled for the first time a one-pot synthesis of non-symmet
Synthesis and in vitro antimalarial activity of tetraoxane-amine/amide conjugates
Kumar, Nitin,Khan, Shabana I.,Atheaya, Himanshu,Mamgain, Ritu,Rawat, Diwan S.
experimental part, p. 2816 - 2827 (2011/07/08)
A series of tetraoxanes, tetraoxane-amine and tetraoxane-amide conjugates have been synthesized and screened for in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Most of the conjugate
Synthesis and X-ray Analysis of Dihydro-1,2,4,5-trioxazine. Evidence of a Steowise Mechanism for the Cycloaddition of Carbonyl Oxides with Nitrones
Mori, Mitsuyuki,Sugiyama, Tomohito,Nojima, Masatomo,Kusabayashi, Shigekazu,McCullough, Kevin J.
, p. 2285 - 2294 (2007/10/02)
Carbonyl oxides, derived by ozonolysis of vinyl ethers, readily undergo cycloaddition reactions with nitrones affording dihydro-1,2,4,5-trioxazines in fair to excellent yield.The structures of dihydro-3,5,6-triphenyl-1,2,4,5-trioxazine (5f) and dihydro-3-cyclohexyl-5-methyl-6,6-diphenyl-1,2,4,5-trioxazine (5t) were unambiguously determined by X-ray analysis.Ozonolysis of 1-cyclohexyl-2-methoxyethene in the presence of either (E)- or (Z)-α-(4-methylphenyl)-α-phenyl-N-methylnitrone gave a 1:1 mixture of two stereoisomeric cycloadducts.This result, in conjunction with the structure of the relevant 5t, suggests that the cycloaddition proceeds by a stepwise mechanism.
