1620752-80-8

Basic information

• Product Name: ethyl 5-oxo-2-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-b]isoquinoline-10-carboxylate
• Synonyms: ethyl 5-oxo-2-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-b]isoquinoline-10-carboxylate
• CAS NO: 1620752-80-8
• Molecular Weight: 333.346
• Mol File: 1620752-80-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 5-oxo-2-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-b]isoquinoline-10-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-oxo-2-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-b]isoquinoline-10-carboxylate(1620752-80-8)
• EPA Substance Registry System: ethyl 5-oxo-2-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-b]isoquinoline-10-carboxylate(1620752-80-8)

Safety Data

• Hazardous Substances Data: 1620752-80-8(Hazardous Substances Data)

Upstream product

• 29418-67-5 2-bromobenzohydrazide 
• 100-52-7 benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 610-94-6 2-bromobenzoic acid methyl ester 

Relevant articles and documents

An integration of condensation/Ullmann-type coupling/bicyclization sequences: Copper-catalyzed three-component direct synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones

A highly efficient three-component domino protocol has been developed for the synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones from simple and readily available o-halogenated benzohydrazides, aldehydes and nitriles. This domino process involves sequential selective condensation, copper-catalyzed intermolecular C-arylation and bicyclization. Notably, the use of ligands and anaerobic conditions can be avoided in this reaction.