1621967-95-0

Basic information

• Product Name: 3-butyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
• Synonyms: 3-butyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
• CAS NO: 1621967-95-0
• Molecular Weight: 284.382
• Mol File: 1621967-95-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-butyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-butyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one(1621967-95-0)
• EPA Substance Registry System: 3-butyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one(1621967-95-0)

Safety Data

• Hazardous Substances Data: 1621967-95-0(Hazardous Substances Data)

Upstream product

• 73591-08-9 3-methoxy-2-phenylacrylonitrile 
• 22252-92-2 3-hydroxy-2-phenylacrylonitrile 
• 82437-64-7 methyl 3-amino-4-phenyl-2-thiophenecarboxylate 
• 109-73-9 N-butylamine 
• 122-51-0 orthoformic acid triethyl ester 
• 140-29-4 phenylacetonitrile 

Relevant articles and documents

Synthesis and biological evaluation of N3-alkyl-thienopyrimidin-4-ones as mGluR1 antagonists

Metabotropic glutamate receptor subtype 1 (mGluR1) is a potential target for the treatment of neuropathic pain, and there has been much effort to discover mGluR1 antagonists. In this study, a series of N3-alkyl-thienopyrimidin-4-ones were prepared by introducing various alkyl and aryl groups to the N3- and 7-positions of the thienopyrimidin-4-one core structure, respectively, and their inhibitory activities against mGluR1 were biologically evaluated. Structure-activity relationship study revealed that the trans-4-methylcyclohexyl, cycloheptyl, and cyclooctyl groups at N3-position, and 2-fluorophenyl group at 7-position were most effective in potentiating the inhibitory activity of the thienopyrimidin-4-one derivatives against mGluR1. Among the synthesized compounds, 3-cyclooctyl-7-phenylthienopyrimidin-4-one and 3-cycloheptyl-7-(2-fluorophenyl)thienopyrimidin-4-one exhibited the most potent inhibitory activities with IC50 values of 115 and 107 nM, respectively.