1622-58-8Relevant articles and documents
REDUCTION OF BENZIMIDAZOLE-2-SULFONIC ACIDS
Popov, I. I.,Boroshko, S. L.,Tertov, B. A.
, p. 224 (1984)
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Condensation reactions of vinyl and ethyl derivatives of 2-amino-and 2-formylimidazoles
Balkalova,Domnina,Chipanina,Afonin,Shulunova
, p. 962 - 966 (1999)
New Schiff bases of 1-vinyl-and 1-ethyl-substituted imidazoles and benzimidazoles were synthesized. The condensation reactions of 2-amino-and 2-formylimidazoles with 2-aminobenzimidazoles are virtually independent of the nature of the substituent (CH=CH2 or Et) at position 1 of the heterocycle. The structures of the azomethines synthesized were established by 1H NMR and IR spectroscopy.
Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles
Spasov,Zhukovskaya,Brigadirova,Abbas,Anisimova,Sysoeva,Rashchenko,Litvinov,Mayka, O. Yu.,Babkov,Morkovnik
, p. 1905 - 1912 (2018/02/06)
An efficient method for the synthesis of novel 9H-imidazo[1,2-a]benzimidazole derivatives containing a biphenyl substituent at position 2 was developed. These compounds, belonging to the privileged substructures, have been tested for a wide range of pharmacological activities in the in vitro test panel. It was shown that the synthesized derivatives demonstrated high antioxidant activity, some of them inhibit type 1B protein tyrosine phosphatase, activate AMP-activated protein kinase, possess antiplatelet properties, and a rare and very interesting kind of activity, the ability to break cross-links of glycated proteins. The most active compounds can be suggested for further optimization.
Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors
Christodoulou, Michael S.,Colombo, Francesco,Passarella, Daniele,Ieronimo, Gabriella,Zuco, Valentina,De Cesare, Michelandrea,Zunino, Franco
body text, p. 1649 - 1657 (2011/04/21)
Since activation of p53 in response to cytotoxic stress may have proapoptotic or protective effects depending on the nature of the injury, inhibitors of p53 may have therapeutic interest as modulators of chemotherapy toxicity or efficacy. In an attempt to
