1622349-81-8

Basic information

• Product Name: methyl 1-(4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzamido)cyclopentanecarboxylate
• Synonyms: methyl 1-(4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzamido)cyclopentanecarboxylate
• CAS NO: 1622349-81-8
• Molecular Weight: 451.479
• Mol File: 1622349-81-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 1-(4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzamido)cyclopentanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzamido)cyclopentanecarboxylate(1622349-81-8)
• EPA Substance Registry System: methyl 1-(4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzamido)cyclopentanecarboxylate(1622349-81-8)

Safety Data

• Hazardous Substances Data: 1622349-81-8(Hazardous Substances Data)

Upstream product

• 702669-44-1 4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzoic acid 
• 78388-61-1 cycloleucine methyl ester 
• 150-13-0 4-amino-benzoic acid 
• 60421-23-0 cycloleucine methyl ester hydrochloride 
• 574-17-4 1-acetyl-1H-indole-2,3-dione 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

OxymaPure/DIC: An efficient reagent for the synthesis of a novel series of 4-[2-(2-acetylaminophenyl)-2-oxo-acetylamino] benzoyl amino acid ester derivatives

OxymaPure (ethyl 2-cyano-2-(hydroxyimino)acetate) was tested as an additive for use in the carbodiimide (DIC) approach for the synthesis of a novel series of α-ketoamide derivatives (4-[2-(2-acetylaminophenyl)-2-oxo-acetylamino] benzoyl amino acid ester derivatives). OxymaPure showed clear superiority to HOBt/DIC or carbodiimide alone in terms of purity and yield. The title compounds were synthesized via the ring opening of N-acylisatin. First, N-acetylisatin was reacted with 4-aminobenzoic acid under conventional heating as well as microwave irradiation to afford 4-(2-(2-acetamidophenyl)-2-oxoacetamido)benzoic acid. This α-ketoamide was coupled to different amino acid esters using OxymaPure/DIC as a coupling reagent to afford 4-[2-(2-acetylaminophenyl)-2- oxoacetylamino] benzoyl amino acid ester derivatives in excellent yield and purity. The synthesized compounds were characterized using FT-IR, NMR, and elemental analysis.