1622880-27-6

Basic information

• Product Name: C₂₃H₂₇N₅O₃
• CAS NO: 1622880-27-6
• Molecular Weight: 421.499
• Mol File: 1622880-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇N₅O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇N₅O₃(1622880-27-6)
• EPA Substance Registry System: C₂₃H₂₇N₅O₃(1622880-27-6)

Safety Data

• Hazardous Substances Data: 1622880-27-6(Hazardous Substances Data)

Upstream product

• 180340-70-9 methyl 6-amino-5-bromopyridine-3-carboxylate 
• 1622880-49-2 C₁₄H₁₄BrN₃O₄ 
• 1622880-50-5 C₁₃H₁₂BrN₃O₄ 
• 1622880-51-6 C₁₅H₁₅N₃O₅ 
• 1632995-69-7 C₁₀H₇BrN₂O₄ 
• 632-14-4 1,1,3-trimethylurea 
• 1622880-57-2 C₂₁H₂₂N₄O₄ 

Relevant articles and documents

Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine- 7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents

Optimization of AZD6482 (2), the first antiplatelet PI3Kβ inhibitor evaluated in man, focused on improving the pharmacokinetic profile to a level compatible with once daily oral dosing as well as achieving adequate selectivity towards PI3Kα to minimize the risk for insulin resistance. Structure-based design and optimization of DMPK properties resulted in (R)-16, a novel, orally bioavailable PI3Kβ inhibitor with potent in vivo anti-thrombotic effect with excellent separation to bleeding risk and insulin resistance.