162358-06-7Relevant articles and documents
Synthesis of FTY720 (Fingolimod) Derivatives Containing Serine Structure
Oh, Yoon Sin,Lee, Taeho,Shin, Sang Mi,Shrestha, Jitendra,Lee, Doohyun,Park, Eun-Young,Baek, Dong Jae
supporting information, p. 261 - 264 (2018/02/14)
-
PROCESS FOR PREPARATION OF FINGOLIMOD
-
Paragraph 0189, (2015/02/18)
The present invention provides a process for preparation of fingolimod, a compound of Formula I or a pharmaceutically acceptable salt thereof, free of regioisomeric impurity compound of Formula IA
SELECTIVE INHIBITORS AND ALLOSTERIC ACTIVATORS OF SPHINGOSINE KINASE
-
Page/Page column 50-51, (2014/08/19)
Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases, such as cancer and vascular remodeling in pulmonary arterial hypertension. Inhibitors of sphingosine kinase 1 and 2 (SK1 and SK2), which catalyze the synthesis of S1P, may be useful anti- proliferative agents. We have synthesized a series of sphingosine-based inhibitors of SK and SK2. Also provided in this invention are compounds that activate SK1 which can be used in diseases such as fibrosis, where intracellular S1P is anti-fibrotic.