16237-97-1

Basic information

• Product Name: Benzofuran, 5-nitro-2-phenyl-
• CAS NO: 16237-97-1
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• Mol File: 16237-97-1.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Benzofuran, 5-nitro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 5-nitro-2-phenyl-(16237-97-1)
• EPA Substance Registry System: Benzofuran, 5-nitro-2-phenyl-(16237-97-1)

Safety Data

• Hazardous Substances Data: 16237-97-1(Hazardous Substances Data)

Upstream product

• 32220-52-3 2'-hydroxy-5'-nitro-deoxybenzoin 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 89487-91-2 2-iodo-4-nitrophenol 
• 536-74-3 phenylacetylene 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 97-51-8 5-Nitrosalicylaldehyde 
• 1719-19-3 2-Methyl-4-phenyl-3-butyn-2-ol 
• 63801-96-7 2-bromo-4-nitrophenyl acetate 
• 100-02-7 4-nitro-phenol 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 1336808-65-1 C₈H₅Br₂NO₃ 
• 873-55-2 sodium benzenesulfonate 
• 100-42-5 styrene 

Downstream Products

• 77084-15-2 2-phenylbenzofuran-5-amine 

Relevant articles and documents

Novel and selective palladium-catalyzed annulations of 2-alkynylphenols to form 2-substituted 3-halobenzo[b]furans

A novel and selective palladium-catalyzed annulation of 2-alkynylphenols method for the synthesis of 2-substituted 3-halobenzo[b]furans is presented. In the presence of PdX2, CuX2, and HEt3NX, 2-substituted 3-halobenzo[b]f

Synthesis and in vitro study of nitro- and methoxy-2-phenylbenzofurans as human monoamine oxidase inhibitors

A new series of 2-phenylbenzofuran derivatives were designed and synthesized to determine relevant structural features for the MAO inhibitory activity and selectivity. Methoxy substituents were introduced in the 2-phenyl ring, whereas the benzofuran moiety was not substituted or substituted at the positions 5 or 7 with a nitro group. Substitution patterns on both the phenyl ring and the benzofuran moiety determine the affinity for MAO-A or MAO-B. The 2-(3-methoxyphenyl)-5-nitrobenzofuran 9 was the most potent MAO-B inhibitor (IC50 = 0.024 μM) identified in this series, whereas 7-nitro-2-phenylbenzofuran 7 was the most potent MAO-A inhibitor (IC50 = 0.168 μM), both acting as reversible inhibitors. The number and position of the methoxyl groups on the 2-phenyl ring, have an important influence on the inhibitory activity. Molecular docking studies confirmed the experimental results and highlighted the importance of key residues in enzyme inhibition.

Fabrication of an amyloid fibril-palladium nanocomposite: A sustainable catalyst for C-H activation and the electrooxidation of ethanol

Amyloids are highly ordered nanofibrils and their tensile strength is similar to that of steel, which makes them resistant to extreme pH and temperature. Based on this rationale, we demonstrate a facile synthesis of palladium, copper, platinum, gold and silver nanocomposites using α-Synuclein (α-Syn) fibrils as a template. We showed that an α-Syn-fibril-palladium nanoparticles (α-Syn-PdNPs) composite can be used as a heterogeneous catalyst in C-H bond activation and the electrooxidation of ethanol. The study demonstrated α-Syn-PdNPs to be a superior heterogeneous catalyst for the synthesis of pharmaceutically valuable benzofuran, naphthofuran, coumarin and N-arylindole via C-H activation. Further, the electrooxidation of ethanol using α-Syn-PdNPs displayed an electrochemically active surface area of 160.6 m2 g-1, which is much higher than the previously reported values for supported Pd nanocomposites.