16241-30-8

Basic information

• Product Name: 5-(4-methoxyphenyl)tropolone
• Synonyms: 5-(4-methoxyphenyl)tropolone
• CAS NO: 16241-30-8
• Molecular Weight: 228.247
• Mol File: 16241-30-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxyphenyl)tropolone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)tropolone(16241-30-8)
• EPA Substance Registry System: 5-(4-methoxyphenyl)tropolone(16241-30-8)

Safety Data

• Hazardous Substances Data: 16241-30-8(Hazardous Substances Data)

Upstream product

• 16235-52-2 4-<4-Methoxy-phenyl>-tropon 
• 29304-87-8 7-(4-methoxyphenyl)cyclohepta-1,3,5-triene 
• 16241-27-3 7-Amino-4-<4-methoxy-phenyl>-tropon 
• 3172-00-7 5-bromotropolone 
• 940-00-1 (4-methoxyphenyl)trimethylstannane 
• 107752-64-7 5-(4-aminophenyl)tropolone 
• 107752-52-3 2-amino-5-(4-aminophenyl)tropone 

Downstream Products

• 107752-76-1 2-methoxy-5-(4'-methoxyphenyl)cyclohepta-2,4,6-trien-1-one 

Relevant articles and documents

The Palladium-Mediated Cross Coupling of Bromotropolones with Organostannanes or Arylboronic Acids: Applications to the Synthesis of Natural Products and Natural Product Analogues

The bromotropolones (4), (5) and (10) undergo palladium-mediated cross coupling with a wide range of organostannanes to produce alkenyl-, alkyl- and aryl-substituted tropolones.The methodology has been applied to the synthesis of the monoterpenes β-dolabrin (11), β-thujaplicin (12), 4-isopropyl-7-methoxytropolone (13) and β-thujaplicinol (14).Cross coupling of bromotropolones (4), (5) and (10) with various aryltrimethylstannanes or arylboronic acids has permitted the preparation of the bicyclic colchicine analogues (30)-(43) which have been tested for tubulin-binding activity.The X-ray crystal structure of the most active of these systems, compound (38), is reported.