16260-59-6

Basic information

• Product Name: 2,4-Hexadiyne,1,6-dichloro-
• Synonyms: 1,6-Dichloro-2,4-hexadiyne
• CAS NO: 16260-59-6
• Molecular Formula: C₆H₄Cl₂
• Molecular Weight: 147.00
• Mol File: 16260-59-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 170.62°C (rough estimate)
• Density: 1.1792 (rough estimate)
• Refractive Index: 1.5610 (estimate)
• CAS DataBase Reference: 2,4-Hexadiyne,1,6-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Hexadiyne,1,6-dichloro-(16260-59-6)
• EPA Substance Registry System: 2,4-Hexadiyne,1,6-dichloro-(16260-59-6)

Safety Data

• Hazard Codes: 3:
• Safety Statements: −. See also CHLORINATED HYDROCARBONS, ALIPHATIC." target="_blank">An extremely shock;sensitive explosive. Upon decompositi
• Hazardous Substances Data: 16260-59-6(Hazardous Substances Data)

Usage

General Description

2,4-Hexadiyne,1,6-dichloro- is a chemical compound with the molecular formula C6H6Cl2. It is a clear, colorless liquid with a faint odor, and is insoluble in water. 2,4-Hexadiyne,1,6-dichloro- is primarily used as a building block in the synthesis of various organic compounds, and is not commonly found in consumer products. It is important to handle this chemical with care, as it is classified as a hazardous substance and can cause irritation to the skin, eyes, and respiratory system upon contact. Additionally, it may pose environmental risks if not properly managed and disposed of.

Upstream product

• 3031-68-3 Hexa-2,4-diyne-1,6-diol 
• 624-65-7 2-propynyl chloride 

Downstream Products

• 1072-20-4 Octatriin-(2,4,6) 
• 210365-61-0 1,6-Bis[4-(4,5-diphenyl-2-imidazolyl)phenoxy]-2,4-hexadiyne 
• 75368-10-4 C₁₈H₁₂Cl₂O₄S₂ 
• 67562-16-7 di-cyclohex-1-enyl-hexatriyne 
• 52167-42-7 hexa-1,5-dien-3-yne-2,5-diyldibenzene 
• 22557-06-8 1,8-bis(phenyl)-3,5-octadiyne 
• 126863-94-3 1,2-Dichloro-4-[(Z)-1-(4-chloro-benzenesulfonylmethyl)-pent-1-en-3-ynylsulfanyl]-benzene 
• 126863-88-5 1,2-Dichloro-4-[(E)-1-(4-chloro-benzenesulfonylmethyl)-pent-1-en-3-ynylsulfanyl]-benzene 
• 126863-92-1 C₁₈H₁₄BrClO₂S₂ 
• 126884-25-1 C₁₈H₁₄BrClO₂S₂ 
• 126863-87-4 C₁₈H₁₄Cl₂O₂S₂ 
• 126863-89-6 4-[(E)-1-(4-Chloro-benzenesulfonylmethyl)-pent-1-en-3-ynyl]-morpholine 

Relevant articles and documents

Synthesis of ene-yne-enes by nickel-catalyzed double SN2′ substitution of 1,6-dichlorohexa-2,4-diyne

1,6-Dichlorohexa-2,4-diyne undergoes nickel-catalyzed double substitution with aryl and alkenyl Grignard reagents to provide substituted ene-yne-enes. The reaction is formally an extension of the well-described SN2′-allylic and -propargylic substitution reactions but the mechanism is considerably more complex. The products might function as building blocks for conjugated polymers.

68Ga-Labelled Tropane Analogues for the Visualization of the Dopaminergic System

The development of radiometal-labelled pharmaceuticals for neuroimaging could offer great potential due to easier handling during labelling and availability through radionuclide generator systems. Nonetheless, to date, no such tracers are available for positron emission tomography, primarily owing to the challenge of crossing the blood–brain barrier (BBB) and loss of affinity through chelator attachment. We have prepared a variety of 68Ga-labelled phenyltropanes showing that, through a simple hydrocarbon-linker, it is possible to introduce a chelator onto the lead structure while maintaining its high affinity for hDAT (human dopamine transporter) and simultaneously achieving adequate lipophilicity. One of the candidates, [68Ga]Ga-HBED-hexadiyne-tropane, showed an IC50 value of 66 nM, together with a log D7.4 of 0.96. A μPET study in a hemi-parkinsonian rat model showed a fast wash-out of the tracer, and no specific uptake in the brain, thus implying an inability to penetrate the BBB.

Free Radicals. XXV. Triarylimidazolyl Radicals Containing Triple Bonds in the Side Chain

2,4,5-Triarylimidazoles containing mono- and diacetylene residues in the para position of the benzene ring at C2 were synthesized. Oxidation of these compounds yielded corresponding radicals which were isolated as dimers. The rate constants of