162635-03-2 Usage
Description
Temsirolimus Acetonide, also known as Rapamycin 42-ester derivative, is a white gel-like chemical compound with potent immunosuppressive and antiproliferative properties. It is a derivative of the macrolide antibiotic Rapamycin, which is produced by the bacterium Streptomyces hygroscopicus. The compound has been found to be effective in inhibiting the activation and proliferation of T and B cells, making it a promising pharmaceutical candidate for various applications.
Uses
Used in Pharmaceutical Industry:
Temsirolimus Acetonide is used as an immunosuppressive agent for preventing organ transplant rejection and treating autoimmune diseases. It works by inhibiting the activation and proliferation of T and B cells, which play a crucial role in the immune response against transplanted organs and contribute to the pathology of autoimmune disorders.
Used in Anticancer Applications:
Temsirolimus Acetonide is employed as an anticancer agent, particularly against solid malignancies such as kidney, breast, and neuroendocrine tumors. It modulates several oncological signaling pathways, including the mTOR pathway, exerting inhibitory effects on tumor growth and progression. Additionally, it demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To overcome the limitations of Temsirolimus Acetonide, such as poor solubility and bioavailability, novel drug delivery systems have been developed to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles, as well as liposomal formulations, have been employed as carriers for Temsirolimus Acetonide delivery, aiming to improve its pharmacokinetics, biodistribution, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 162635-03-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,6,3 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 162635-03:
(8*1)+(7*6)+(6*2)+(5*6)+(4*3)+(3*5)+(2*0)+(1*3)=122
122 % 10 = 2
So 162635-03-2 is a valid CAS Registry Number.
InChI:InChI=1/C59H91NO16/c1-35-19-15-14-16-20-36(2)47(69-11)31-43-24-22-41(7)59(68,76-43)53(64)54(65)60-26-18-17-21-44(60)55(66)74-48(32-45(61)37(3)28-40(6)51(63)52(71-13)50(62)39(5)27-35)38(4)29-42-23-25-46(49(30-42)70-12)75-56(67)58(10)33-72-57(8,9)73-34-58/h14-16,19-20,28,35,37-39,41-44,46-49,51-52,63,68H,17-18,21-27,29-34H2,1-13H3/b16-14+,19-15+,36-20+,40-28+/t35-,37-,38-,39-,41-,42+,43+,44+,46-,47+,48+,49-,51-,52+,59-/m1/s1
162635-03-2Relevant articles and documents
Method for separating and purifying temsirolimus
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Paragraph 0026; 0028, (2019/07/04)
The invention discloses a method for separating and purifying temsirolimus. The method comprises the following steps: (1) synthesis of a crude product; and (2) separation and purification. The specific separation and purification method has the advantages of great improvement of the purity and the yield of temsirolimus, reduction of the cost, and broad market application prospect.
Intermediate of temsirolimus and preparation method thereof
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Paragraph 0062; 0063; 0066; 0067, (2019/01/06)
The invention provides an intermediate of temsirolimus. The intermediate has better selectivity and higher yield when used for preparation of the temsirolimus. The intermediate provided by the invention has a structural formula which is described in the specification.
REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT THE C-42 POSITION
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Page/Page column 7-8, (2012/10/18)
The invention refers to the selective acylation of Rapamycin at the 42-position (I) with an acylating agent of the formula (II) wherein R4 and R5 are the same or different, individually the rest of an acetal, especially tetrahydropyran, or of a carbonate or the rest of a silyl ether or taken together are the rest of a boronate, an acetal or ketal.
