1627-20-9Relevant articles and documents
Synthesis of furanochromones: A new step in improvement of fluorescence properties
Klymchenko, Andrey S.,Ozturk, Turan,Demchenko, Alexander P.
, p. 7079 - 7082 (2002)
New 3-hydroxychromone derivatives with a fused furan heterocycle (2-aryl-3-hydroxyfurano[3,2-g]chromones) have been synthesized. This was achieved by an important improvement in the synthetic procedure. Like their parent analogs, these new compounds exhibit two intensive fluorescence emission bands belonging to normal (N*) and tautomer (T*) excited-state forms. While the spectral position of the N* band remains unchanged, the T* band is shifted to longer wavelengths, providing larger separation between the two bands. The new compounds exhibit increased molecular extinction and, more importantly, have about twice as high fluorescence quantum yields. These properties make them very promising for designing new two-band fluorescence sensors.
Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents
China Raju,Nageswara Rao,Suman,Yogeeswari,Sriram,Shaik, Thokhir Basha,Kalivendi, Shasi Vardhan
scheme or table, p. 2855 - 2859 (2011/06/24)
Series of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 7a-7zb, 8a-8d and 9a-9d were synthesized and screened for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) and cytotoxicity against three human cancer cell lines including A549, SK-N-SH and HeLa. The results indicate that six compounds are more potent and 7za is most effective anti-mycobacterial derivative compared to the standard drugs Ethambutol and Ciprofloxacin. However, 12 compounds exhibited cytotoxicity against human neuroblastoma cell line; amongst them the compound 7v is most effective compared to the standard drug Doxorubicin. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure-activity relationship for this new class of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5- carboxylates.
A controlled synthesis of nature-mimicking benzofurans and their corresponding dimers
Dixit, Manish,Sharon, Ashoke,Maulik, Prakas R.,Goel, Atul
, p. 1497 - 1502 (2007/10/03)
Benzofurans functionalized with hydroxy and acetyl functionalities are not only the core structures found in a large number of biologically important natural products, but also the vital precursors for several naturally occurring furanoflavonoids. Numerou
