162744-47-0

Basic information

• Product Name: 1-Bromo-2-fluoro-4-(methoxymethyl)benzene
• Synonyms: 1-Bromo-2-fluoro-4-(methoxymethyl)benzene;Benzene, 1-broMo-2-fluoro-4-(MethoxyMethyl)-;4-BroMo-3-fluoro-1-(MethoxyMethyl)benzene
• CAS NO: 162744-47-0
• Molecular Formula: C₈H₈BrFO
• Molecular Weight: 219.052
• Mol File: 162744-47-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 212.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.470±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Bromo-2-fluoro-4-(methoxymethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-fluoro-4-(methoxymethyl)benzene(162744-47-0)
• EPA Substance Registry System: 1-Bromo-2-fluoro-4-(methoxymethyl)benzene(162744-47-0)

Safety Data

• Hazardous Substances Data: 162744-47-0(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-fluoro-4-(methoxymethyl)benzene is a chemical compound with the molecular formula C8H8BrFOCH3. It is a clear, colorless liquid with a slightly sweet odor, and it is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1-Bromo-2-fluoro-4-(methoxymethyl)benzene is a derivative of benzene, containing a bromine and a fluorine atom as well as a methoxymethyl group attached to the benzene ring. It is primarily used in the production of various chemicals and is also used as a reagent in organic synthesis. 1-Bromo-2-fluoro-4-(methoxymethyl)benzene is considered to be a moderately hazardous chemical and should be handled with caution.

Upstream product

• 222978-01-0 4-bromo-3-fluorobenzyl alcohol 
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• 124-63-0 methanesulfonyl chloride 
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• 67-56-1 methanol 
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Relevant articles and documents

BENZOTHIOPHENE DERIVATIVE

[Problem to be Solved] It is intended to provide a compound having PDE10A inhibitory activity and having a novel structure, or an isotope thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. [Solution] The present invention provides a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof.

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with Ki 50 100 nM; PGD2-induced eosinophil shape change). Additional optimization of the PK characteristics led to the identification of several compounds suitable for in vivo testing. Of these, 19k and 19s were tested in two different pharmacological models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg).