1627500-27-9

Basic information

• Product Name: C₂₀H₁₆FNO
• Synonyms: C₂₀H₁₆FNO
• CAS NO: 1627500-27-9
• Molecular Weight: 305.352
• Mol File: 1627500-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₆FNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₆FNO(1627500-27-9)
• EPA Substance Registry System: C₂₀H₁₆FNO(1627500-27-9)

Safety Data

• Hazardous Substances Data: 1627500-27-9(Hazardous Substances Data)

Upstream product

• 1008-89-5 2-phenylpyridine 
• 201230-82-2 carbon monoxide 
• 394-46-7 2-fluorostyrene 

Relevant articles and documents

Ruthenium-catalyzed hydroaroylation of styrenes in water through directed C-H bond activation

Selective C-H bond-functionalization reactions of arenes offer the potential for a more benign synthesis of fine chemicals and organic building blocks for the life science industries. In this respect, direct carbonylative coupling reactions of (hetero)arenes allow for the straightforward synthesis of (hetero)aromatic ketones and related derivatives. Herein, we present an efficient ruthenium(II)-catalyzed carbonylative hydroarylation of alkenes through directed C-H functionalization. More specifically, the carbonylative hydroarylation of styrenes with 2-aryl- (heteroaryl)pyridines and related derivatives proceeds selectively and with 100 % atom efficiency in water as the solvent. Three-Component Hydroaroylation: Hydroaroylation through C-H activation of (hetero)arenes bearing ortho-directing groups (DGs) proceeds in the presence of a ruthenium catalyst, carbon monoxide, and styrenes. The shown coupling process provides selective and atom-economic access to (hetero)- aromatic ketones.