16283-66-2

Basic information

• Product Name: 3-Methylquinuclidin-3-ol
• Synonyms: 3-Methylquinuclidin-3-ol
• CAS NO: 16283-66-2
• Molecular Formula: C8H15NO
• Molecular Weight: 141.2108
• Mol File: 16283-66-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Methylquinuclidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methylquinuclidin-3-ol(16283-66-2)
• EPA Substance Registry System: 3-Methylquinuclidin-3-ol(16283-66-2)

Safety Data

• Hazardous Substances Data: 16283-66-2(Hazardous Substances Data)

Upstream product

• 917-54-4 methyllithium 
• 1193-65-3 3-quinuclidinone hydrochloride 
• 3731-38-2 3-Quinuclidinone 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 1401090-48-9 (S)-1-(1-(4'-fluorobiphenyl-4-yl)cyclopropyl)-3-(3-methylquinuclidin-3-yl)urea 
• 21638-13-1 3-methylquinuclidin-3-amine 
• 1580436-57-2 4-([1,1'-biphenyl]-4-yl)-N-(3-methylquinuclidin-3-yl)piperazine-1-carboxamide 
• 1580436-89-0 1-(4'-fluoro-[1,1'-biphenyl]-3-yl)-N-(3-methylquinuclidin-3-yl)piperidine-4-carboxamide 

Relevant articles and documents

Hydroalkylation of Unactivated Olefins via Visible-Light-Driven Dual Hydrogen Atom Transfer Catalysis

Radical hydroalkylation of olefins enabled by hydrogen atom transfer (HAT) catalysis represents a straightforward means to access C(sp3)-rich molecules from abundant feedstock chemicals without the need for prefunctionalization. While Giese-type hydroalkylation of activated olefins initiated by HAT of hydridic carbon-hydrogen bonds is well-precedented, hydroalkylation of unactivated olefins in a similar fashion remains elusive, primarily owing to a lack of general methods to overcome the inherent polarity-mismatch in this scenario. Here, we report the use of visible-light-driven dual HAT catalysis to achieve this goal, where catalytic amounts of an amine-borane and an in situ generated thiol were utilized as the hydrogen atom abstractor and donor, respectively. The reaction is completely atom-economical and exhibits a broad scope. Experimental and computational studies support the proposed mechanism and suggest that hydrogen-bonding between the amine-borane and substrates is beneficial to improving the reaction efficiency.

Glucosylceramide synthase inhibitors

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.