16284-60-9 Usage
Description
N-Isovalerylglycine, also known as isovaleryl glycine, is a compound found in the urine of patients with isovaleric acidemia, a disorder caused by defective leucine metabolism due to a deficiency in the isovaleryl coenzyme A dehydrogenase. It is an N-acylglycine in which the acyl group is specified as isovaleryl and is characterized by its white to off-white solid appearance. N-Isovalerylglycine has been used as a diagnostic tool in the diagnosis of various acidemias and mitochondrial fatty acid β-oxidation defects.
Uses
Used in Diagnostic Applications:
N-Isovalerylglycine is used as a diagnostic tool for identifying and monitoring various organic acidemias and mitochondrial fatty acid β-oxidation defects. It is particularly useful in the detection of isovaleric acidemia, an inborn error of leucine metabolism.
Used in Medical Industry:
N-Isovalerylglycine is used as a diagnostic marker in the medical industry for the early detection and diagnosis of isovaleric acidemia and other related metabolic disorders. Its presence in the urine of affected patients aids in the identification of these conditions, enabling timely intervention and treatment.
Used in Research and Development:
N-Isovalerylglycine is also utilized in research and development for the study of metabolic pathways, enzyme deficiencies, and the development of novel therapeutic strategies for the treatment of isovaleric acidemia and other related metabolic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 16284-60-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,8 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16284-60:
(7*1)+(6*6)+(5*2)+(4*8)+(3*4)+(2*6)+(1*0)=109
109 % 10 = 9
So 16284-60-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO3/c1-5(2)3-6(9)8-4-7(10)11/h5H,3-4H2,1-2H3,(H,8,9)(H,10,11)
16284-60-9Relevant articles and documents
Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification
Zhu, Mengyi,Wang, Lijuan,He, Jing
supporting information, p. 2030 - 2035 (2020/11/30)
Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.
Composition for enhancing lipid production, barrier function, hydrogen peroxide neutralization, and moisturization of the skin
-
, (2008/06/13)
Increased production of skin lipids, increased barrier function, hydrogen peroxide neutralization, prevention of loss of the natural moisturizing factor from the stratum corneum and moisturization of the skin is provided by a topically applicable composition which includes one or more components selected from the group consisting of branched chain amino acids, derivatives of branched chain amino acids and mixtures thereof, which one or more components are capable of being catabolized in epidermal cells to form lipid precursors for epidermal lipid synthesis. The composition can also include one or more enzyme activators which increase the rate of catabolism of the one or more components.
