16285-74-8

Basic information

• Product Name: THIENO[3,2-D]PYRIMIDIN-4-AMINE
• Synonyms: THIENO[3,2-D]PYRIMIDIN-4-AMINE;4-Aminothieno[3,2-d]pyrimidine
• CAS NO: 16285-74-8
• Molecular Formula: C₆H₅N₃S
• Molecular Weight: 151.19
• Mol File: 16285-74-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 226 °C
• Boiling Point: 346.799°C at 760 mmHg
• Flash Point: 163.538°C
• Appearance: /
• Density: 1.486g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.785
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Acetonitrile (Slightly), DMSO (Slightly)
• PKA: 5.39±0.30(Predicted)
• CAS DataBase Reference: THIENO[3,2-D]PYRIMIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: THIENO[3,2-D]PYRIMIDIN-4-AMINE(16285-74-8)
• EPA Substance Registry System: THIENO[3,2-D]PYRIMIDIN-4-AMINE(16285-74-8)

Safety Data

• Hazardous Substances Data: 16285-74-8(Hazardous Substances Data)

Usage

Uses

4-Aminothieno[3,2-d]pyrimidine is a useful research intermediate

InChI:InChI=1/C6H5N3S/c7-6-5-4(1-2-10-5)8-3-9-6/h1-3H,(H2,7,8,9)

Upstream product

• 16269-66-2 4-chlorothieno[3,2-d]pyrimidine 

Relevant articles and documents

Discovery and optimization of 1-(4-chloro-3-(trifluoromethyl)-phenyl)-3-(2-(amino)pyridin-3-yl)ureas as novel kdr kinase inhibitors

Kinase insert Domain-containing Receptor (KDR) is one of the currently validated targets for anticancer drug discovery and development. Herein, a series of o-amino-arylurea derivatives have been synthesized and evaluated for their kinase inhibitory activity. The optimization on the basis of biological screening and molecular modeling resulted in obvious increase in KDR kinase inhibitory activity compared with the hit compound. Eventually, we identified a potent inhibitor 5a of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-((quinolin-4-ylmethyl) amino)pyridin-3-yl)urea scaffold against KDR (IC50 = 0.0689 μM), which can serve as good starting point for further KDR inhibitor optimization and development.