1628785-14-7

Basic information

• Product Name: C₁₅H₉ClN₂O₂
• Synonyms: C₁₅H₉ClN₂O₂
• CAS NO: 1628785-14-7
• Molecular Weight: 284.702
• Mol File: 1628785-14-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₅H₉ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₉ClN₂O₂(1628785-14-7)
• EPA Substance Registry System: C₁₅H₉ClN₂O₂(1628785-14-7)

Safety Data

• Hazardous Substances Data: 1628785-14-7(Hazardous Substances Data)

Upstream product

• 31374-18-2 7-chloro-3,4-dihydroquinazolin-4-one 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 2148-57-4 4,7-dichloroquinazoline 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 1620139-20-9 dibenzyl 2-((benzo[d]thiazol-2-ylamino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate 
• 1620139-24-3 dibenzyl 2-(((6-chlorobenzo[d]thiazol-2-yl)amino)(4-((7-chloroquinazolin-4-yl)oxy)phenyl)methyl)malonate 
• 1620139-28-7 dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methoxybenzo[d]thiazol-2-yl)amino)methyl)malonate 
• 1620139-31-2 dibenzyl 2-((4-((7-chloroquinazolin-4-yl)oxy)phenyl)((6-methylbenzo[d]thiazol-2-yl)amino)methyl)malonate 

Relevant articles and documents

Syntheses, antiviral activities and induced resistance mechanisms of novel quinazoline derivatives containing a dithioacetal moiety

A series of novel quinazoline derivatives containing a dithioacetal moiety were designed and synthesized, and their structures were characterized by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry. Bioassay results indicated that compound 4b exhibited remarkable protective activity against cucumber mosaic virus (CMV, EC50 = 248.6 μg/mL) and curative activity against potato virus Y (EC50 = 350.5 μg/mL), which were better than those of ningnanmycin (357.7 μg/mL and 493.7 μg/mL, respectively). Moreover, compound 4b could increase the chlorophyll content in plants, improve photosynthesis, and effectively induce tobacco anti-CMV activity.

Synthesis and anti-TMV activity of novel β-amino acid ester derivatives containing quinazoline and benzothiazole moieties

Here, a series of β-amino acid ester derivatives containing quinazoline and benzothiazoles was synthesized and evaluated for anti-tobacco mosaic virus (TMV) activity. The compounds 3n, 3o, 3p and 3q showed good antiviral activity against TMV at a concentration of 500 μg/mL, with curative rates of 55.55%, 52.32%, 52.77% and 50.91%, respectively, and protection rates of 52.33%, 55.96%, 54.21% and 50.98%, respectively. These values were close to those of the commercially available antiviral agent ningnanmycin (which has curative and protection rates of 55.27% and 52.16%, respectively). To our knowledge, this is the first report of the anti-TMV activity of β-amino acid ester derivatives containing quinazoline and benzothiazoles moieties; the results indicate that these novel compounds can potentially be used as protective agents against TMV diseases.