1629162-14-6

Basic information

• Product Name: (R)-benzyl 3-tert-butyl-4-oxo-1-(pyridin-3-yl)-2,3-diazaspiro[4.4]nona-1,7-diene-7-carboxylate
• CAS NO: 1629162-14-6
• Molecular Weight: 403.481
• Mol File: 1629162-14-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-benzyl 3-tert-butyl-4-oxo-1-(pyridin-3-yl)-2,3-diazaspiro[4.4]nona-1,7-diene-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-benzyl 3-tert-butyl-4-oxo-1-(pyridin-3-yl)-2,3-diazaspiro[4.4]nona-1,7-diene-7-carboxylate(1629162-14-6)
• EPA Substance Registry System: (R)-benzyl 3-tert-butyl-4-oxo-1-(pyridin-3-yl)-2,3-diazaspiro[4.4]nona-1,7-diene-7-carboxylate(1629162-14-6)

Safety Data

• Hazardous Substances Data: 1629162-14-6(Hazardous Substances Data)

Upstream product

• 1212022-43-9 benzyl 2-(acetoxymethyl)buta-2,3-dienoate 
• 1629161-95-0 1-tert-butyl-3-(pyridin-3-yl)-1H-pyrazol-5(4H)-one 
• 6283-81-4 3-oxo-3-pyridin-3-yl-propionic acid ethyl ester 

Relevant articles and documents

Asymmetric synthesis of spiropyrazolones through phosphine-catalyzed [4+1] annulation

An enantioselective synthesis of spiropyrazolones from allenoate-derived MBH acetates and pyrazolones through a phosphine-mediated [4+1] annulation process has been developed. Spiropyrazolones were readily prepared in good chemical yields and good to high enantioselectivities. This is the first asymmetric example in which α-substituted allenoates were utilized as a C4 synthon for phosphine-catalyzed [4+1] annulation. Optically enriched 4-spiro-5-pyrazolones were prepared through phosphine-catalyzed enantioselective [4+1] annulation. In this study, substituted pyrazolones were used as a C1 synthon in cycloaddition for the first time. Moreover, this is the first report in which α-substituted allenoates were utilized in an asymmetric [4+1] annulation.