16299-22-2

Basic information

• Product Name: 6-Methyl-4-phenylcoumarin
• Synonyms: 6-Methyl-4-phenylcoumarin;6-Methyl-4-phenyl-2H-1-benzopyran-2-one
• CAS NO: 16299-22-2
• Molecular Formula: C₁₆H₁₂O₂
• Molecular Weight: 236.26528
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 16299-22-2.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 6-Methyl-4-phenylcoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-4-phenylcoumarin(16299-22-2)
• EPA Substance Registry System: 6-Methyl-4-phenylcoumarin(16299-22-2)

Safety Data

• Hazardous Substances Data: 16299-22-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Intermediate in the production ot Tolterodine and related coumarin derivatives.

Upstream product

• 106-44-5 p-cresol 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 10034-85-2 hydrogen iodide 
• 345948-96-1 6-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 98-80-6 phenylboronic acid 
• 7299-58-3 phenylpropiolyl chloride 
• 911217-72-6 C₁₇H₁₁F₁₃O₃ 
• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 108-24-7 acetic anhydride 
• 637-44-5 phenylpropyolic acid 
• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 55359-68-7 2-(methoxymethoxy)-5-methylbenzaldehyde 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 51069-75-1 4-chloro-6-methyl-2H-chromen-2-one 

Downstream Products

• 827007-19-2 (R)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one 
• 349547-18-8 (S)-6-methyl-4-phenylchroman-2-one 
• 828933-86-4 (4R)-6-methyl-4-phenylchroman-2-ol 
• 851789-43-0 3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1 
• 851789-51-0 (R)-2-(3-hydroxy-1-phenylpropyl)-4-methylphenol 
• 851789-53-2 (S)-2-(3-hydroxy-1-phenylpropyl)-4-methylphenol 
• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 73779-10-9 3-(2-hydroxy-5-methyl-phenyl)-3-phenyl-propionic acid 
• 124937-51-5 (R)-(+)-tolterodine 
• 124937-53-7 (S)-tolterodine 

Relevant articles and documents

Magnetothermia-Induced Catalytic Hollow Nanoreactor for Bioorthogonal Organic Synthesis in Living Cells

Nanoreactors, in which the reactions are remotely controlled by magnetic fields, are potentially valuable in bioorthogonal chemistry for future applications. Here, we develop a silica-confined magnetothermia-induced nanoreactor (MAG-NER) by selectively gr

Metal-free annulative hydrosulfonation of propiolate esters: synthesis of 4-sulfonates of coumarins and butenolides

An efficient metal-free and cost-effective method for the synthesis of coumarin and butenolide 4-sulfonates (46 examples) has been developed. The reaction involves addition of sulfonic acids to ethyl propiolates followed by lactonization, resulting in direct formation of coumarin and butenolide 4-sulfonates. This methodology has been elaborated to Sonogashira and Suzuki coupling including the synthesis of rac-tolterodine.

Zeolite-promoted Synthesis of Coumarins and Thiocoumarins

Acidic zeolites, especially faujasites, efficiently promote the intramolecular cyclization of aryl propynoates and propynethioates, which produces coumarins and thiocoumarins, usually in high yields. Comparison with homogeneous Lewis or Br?nsted acids and