162997-84-4

Basic information

• Product Name: Z-Thr(t-Bu)-Thr(t-Bu)-O(t-Bu)
• CAS NO: 162997-84-4
• Molecular Weight: 522.682
• Mol File: 162997-84-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-Thr(t-Bu)-Thr(t-Bu)-O(t-Bu)(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Thr(t-Bu)-Thr(t-Bu)-O(t-Bu)(162997-84-4)
• EPA Substance Registry System: Z-Thr(t-Bu)-Thr(t-Bu)-O(t-Bu)(162997-84-4)

Safety Data

• Hazardous Substances Data: 162997-84-4(Hazardous Substances Data)

Upstream product

• 5854-78-4 (2S,3R)-tert-butyl 2-amino-3-tert-butoxybutanoate 
• 16966-07-7 (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid dicyclohexylammonium salt 

Downstream Products

• 162997-83-3 Z-Gly-Gly-Gly-Glu(O-t-Bu)-Thr(t-Bu)-Thr(t-Bu)-O-t-Bu 
• 162878-26-4 Z-Glu(O-t-Bu)-Thr(t-Bu)-Thr(t-Bu)-O-t-Bu 

Relevant articles and documents

Synthesis and biological activities of TAN-1511 analogues

TAN-1511 analogues were synthesized and their effects on the proliferation of bone marrow cells were examined. To exert potent activity the following conditions are necessary: the configuration of the 2-amino-6,7-dihydroxy-4-thiaheptanoic acid moiety must be (2R,6R), long chain acyl groups (C14 to C18) must be bound to both hydroxyl groups, the amino group must be free or acylated with the long chain fatty acid (ca. C14) and the peptide moiety must have glutamic acid as a component. Among the synthesized compounds, trisodium (2R,6R)-2-amino-6,7-bis (hexadecanoyloxy)-4-thiaheptanoyl glycyl glutamyl glutamate, which has improved solubility, was effective in experimental leukocytopenia in mice.