163008-86-4

Basic information

• Product Name: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL
• Synonyms: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL;(4-Methyl-1,2,3-thiadiazol-5-yl)methanol;5-(Hydroxymethyl)-4-methyl-1,2,3-thiadiazole;(4-methyl-1,2,3-thiadiazol-5-yl)methanol(SALTDATA: FREE);(4-Methyl-1,2,3-thiadiazol-5-yl)
• CAS NO: 163008-86-4
• Molecular Formula: C₄H₆N₂OS
• Molecular Weight: 130.17
• Product Categories: Hydroxymethyl's;Oxadiazoles & Thiadiazoles;Oxadiazoles & Thiadiazoles
• Mol File: 163008-86-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 261.481 °C at 760 mmHg
• Flash Point: 111.94 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL(163008-86-4)
• EPA Substance Registry System: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL(163008-86-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 163008-86-4(Hazardous Substances Data)

Usage

General Description

4-Methyl-1,2,3-thiadiazole-5-methanol is a chemical compound with the molecular formula C4H6N2OS. It is a heterocyclic compound containing a thiadiazole ring with a methyl and hydroxyl group attached to it. 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL is often used in pharmaceutical and chemical research as a building block for the synthesis of various biologically active molecules and potential drug candidates. It may also have potential applications in the development of new materials and organic synthesis strategies. As a result, 4-Methyl-1,2,3-thiadiazole-5-methanol is of interest to researchers in the fields of medicinal chemistry, organic synthesis, and chemical biology.

InChI:InChI=1/C4H6N2OS/c1-3-4(2-7)8-6-5-3/h7H,2H2,1H3

Upstream product

• 18212-20-9 4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester 
• 183298-93-3 methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate 

Downstream Products

• 127108-66-1 4-methyl-1,2,3-thiadiazole-5-carbaldehyde 

Relevant articles and documents

Synthesis of 1,2,3-thiadiazole and thiazole-based strobilurins as potent fungicide candidates

Strobilurin fungicides play a crucial role in protecting plants against different pathogens and securing food supplies. A series of 1,2,3-thiadiazole and thiazole-based strobilurins were rationally designed, synthesized, characterized, and tested against various fungi. Introduction of 1,2,3-thiadiazole greatly improved the fungicidal activity of the target molecules. Compounds 8a, 8c, 8d, and 10i exhibited a relatively broad spectrum of fungicidal activity. Compound 8a showed excellent activities against Gibberella zeae, Sclerotinia sclerotiorum, and Rhizoctonia cerealis with median effective concentrations (EC50) of 2.68, 0.44, and 0.01 μg/mL, respectively; it was much more active than positive controls enestroburin, kresoxim-methyl, and azoxystrobin with EC50 between 0.06 and 15.12 μg/mL. Comparable or better fungicidal efficacy of compound 8a compared with azoxystrobin and trifloxystrobin against Sphaerotheca fuliginea and Pseudoperonspera cubensis was validated in cucumber fields at the same application dosages. Therefore, compound 8a is a promising fungicidal candidate worthy of further development.

1,2,3-thiadiazole-containing benzoyl hydrazone derivative as well as preparation method and application thereof

The invention belongs to the field of organic compound synthesis and particularly relates to a 1,2,3-thiadiazole-containing benzoyl hydrazone derivative as well as a preparation method and application thereof. The structure of the compound is shown by a f

Synthesis, crystal structure and herbicidal activity of novel 1,2,3-thiadiazole substituted 2-cyanoacrylates

A series of novel 2-cyanoacrylates containing the 1,2,3-thiadiazole ring moiety were synthesized and characterized by 1H NMR, 13C NMR, elemental analysis and, in one case, by X-ray crystallography. Most of these cyanoacrylates exhibi