1630952-76-9

Basic information

• Product Name: (S)-8-(chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
• Synonyms: (S)-8-(chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
• CAS NO: 1630952-76-9
• Molecular Weight: 363.459
• Mol File: 1630952-76-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-8-(chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-8-(chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one(1630952-76-9)
• EPA Substance Registry System: (S)-8-(chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one(1630952-76-9)

Safety Data

• Hazardous Substances Data: 1630952-76-9(Hazardous Substances Data)

Upstream product

• 136669-13-1 4-chloro-3,4-dihydro-2H-chromene 
• 1481-93-2 4-hydroxychroman 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 118-93-4 o-hydroxyacetophenone 
• 1630952-74-7 8-((S)-chroman-4-yl)-1-phenyl-3-((S)-1-tosylpyrrolidine-2-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one 

Relevant articles and documents

Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor

A series of triazospirodecanone derivatives were synthesized as potential NOP ligands. 8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (4) and its 5-fluoro analogue (18) proved to be active as agonists with EC50 values in the submicromolar range. Single enantiomers of compound 4 were separated and tested as NOP agonists; the eutomer R-(+)-4 showed a pEC 50 of 7.34. Finally docking studies were performed on the NOP receptor to identify the most significant stereospecific interactions.